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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

fgf10a  -  fibroblast growth factor 10a

Danio rerio

Synonyms: SO:0000704, fgf-10, fgf10, wu:fd11d03, zgc:109774
 
 
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High impact information on fgf10

  • Furthermore, application of Fgf10 protein can rescue target gene activation in fgf10, but not in ext2 or extl3 mutants [1].
  • We show that the zebrafish fgf24 gene, which belongs to the Fgf8/17/18 subfamily of Fgf ligands, acts downstream of tbx5 to activate fgf10 expression in the lateral plate mesoderm [2].
  • Tbx5, in turn, is required for the activation of fgf10, which relays the limb inducing signal to the overlying ectoderm [2].
  • Recent evidence suggests that AEMF activity is composed of different signals involving both a sonic hedgehog (Shh) signal and a fibroblast growth factor 10 (Fgf10) signal from the mesenchyme [3].
 

Other interactions of fgf10

  • Consistent with this proposal, we observe a strong genetic interaction between fgf10 and extl3 mutants [1].

References

  1. HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development. Norton, W.H., Ledin, J., Grandel, H., Neumann, C.J. Development (2005) [Pubmed]
  2. The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation. Fischer, S., Draper, B.W., Neumann, C.J. Development (2003) [Pubmed]
  3. dackel acts in the ectoderm of the zebrafish pectoral fin bud to maintain AER signaling. Grandel, H., Draper, B.W., Schulte-Merker, S. Development (2000) [Pubmed]
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