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Clint1  -  clathrin interactor 1

Rattus norvegicus

Synonyms: Clint, Enth, Epn4
 
 
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High impact information on Enth

 

Biological context of Enth

  • The Clint increased with the day of gestation, remarkably between the 19th and 21st day of gestation, showing nearly the same developmental profile as the Vmax [4].
 

Anatomical context of Enth

  • In rat hepatocytes with 0.003%, 0.03% and 0.3% (w/v) Solutol HS 15 already present in the incubation medium, the Clint was significantly reduced in a dose-dependent manner by about 25%, 30% and 50%, respectively [5].
  • A reduction in Clint was also observed in experiments with rat liver microsomes [5].
 

Associations of Enth with chemical compounds

References

  1. The clathrin interacting protein Clint/epsinR in rat testicular germ cells. Redecker, P. Histochem. Cell Biol. (2005) [Pubmed]
  2. In vitro metabolism of chlorotriazines: characterization of simazine, atrazine, and propazine metabolism using liver microsomes from rats treated with various cytochrome P450 inducers. Hanioka, N., Jinno, H., Tanaka-Kagawa, T., Nishimura, T., Ando, M. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  3. Malaria infection impairs glucuronidation and biliary excretion by the isolated perfused rat liver. Murdoch, R.T., Ghabrial, H., Mihaly, G.W., Morgan, D.J., Smallwood, R.A. Xenobiotica (1991) [Pubmed]
  4. Developmental change in clearance of glucuronide of p-phenylbenzoic acid from in vitro kinetic parameters and its correlation with clearance from in vivo in fetus of rat. Nanbo, T. J. Pharmacobio-dyn. (1983) [Pubmed]
  5. In vitro investigation on the impact of the surface-active excipients Cremophor EL, Tween 80 and Solutol HS 15 on the metabolism of midazolam. Bravo González, R.C., Huwyler, J., Boess, F., Walter, I., Bittner, B. Biopharmaceutics & drug disposition. (2004) [Pubmed]
  6. First-pass effect and intrinsic clearance of propranolol and pindolol in the isolated perfused rat liver. Basset, H.M., Robins, A.H. S. Afr. Med. J. (1980) [Pubmed]
  7. Stereoselectivity and interaction between the glucuronidation of S-(-)- and R-(+)-propranolol in rat hepatic microsomes pretreated with different inducers. Luan, L.J., Shao, Q., Zeng, S. Die Pharmazie. (2005) [Pubmed]
 
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