The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Clint1  -  clathrin interactor 1

Rattus norvegicus

Synonyms: Clint, Enth, Epn4
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Enth


Biological context of Enth

  • The Clint increased with the day of gestation, remarkably between the 19th and 21st day of gestation, showing nearly the same developmental profile as the Vmax [4].

Anatomical context of Enth

  • In rat hepatocytes with 0.003%, 0.03% and 0.3% (w/v) Solutol HS 15 already present in the incubation medium, the Clint was significantly reduced in a dose-dependent manner by about 25%, 30% and 50%, respectively [5].
  • A reduction in Clint was also observed in experiments with rat liver microsomes [5].

Associations of Enth with chemical compounds


  1. The clathrin interacting protein Clint/epsinR in rat testicular germ cells. Redecker, P. Histochem. Cell Biol. (2005) [Pubmed]
  2. In vitro metabolism of chlorotriazines: characterization of simazine, atrazine, and propazine metabolism using liver microsomes from rats treated with various cytochrome P450 inducers. Hanioka, N., Jinno, H., Tanaka-Kagawa, T., Nishimura, T., Ando, M. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  3. Malaria infection impairs glucuronidation and biliary excretion by the isolated perfused rat liver. Murdoch, R.T., Ghabrial, H., Mihaly, G.W., Morgan, D.J., Smallwood, R.A. Xenobiotica (1991) [Pubmed]
  4. Developmental change in clearance of glucuronide of p-phenylbenzoic acid from in vitro kinetic parameters and its correlation with clearance from in vivo in fetus of rat. Nanbo, T. J. Pharmacobio-dyn. (1983) [Pubmed]
  5. In vitro investigation on the impact of the surface-active excipients Cremophor EL, Tween 80 and Solutol HS 15 on the metabolism of midazolam. Bravo González, R.C., Huwyler, J., Boess, F., Walter, I., Bittner, B. Biopharmaceutics & drug disposition. (2004) [Pubmed]
  6. First-pass effect and intrinsic clearance of propranolol and pindolol in the isolated perfused rat liver. Basset, H.M., Robins, A.H. S. Afr. Med. J. (1980) [Pubmed]
  7. Stereoselectivity and interaction between the glucuronidation of S-(-)- and R-(+)-propranolol in rat hepatic microsomes pretreated with different inducers. Luan, L.J., Shao, Q., Zeng, S. Die Pharmazie. (2005) [Pubmed]
WikiGenes - Universities