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Gene Review:

Pfk - Phosphofructokinase

Drosophila melanogaster

Synonyms: ATP-PFK, ATP-dependent 6-phosphofructokinase, BcDNA.GH12192, BcDNA:GH12192, CG4001, ...

Currie, P.D. et al., Munneke, L.R. et al.

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High impact information on Pfk

Deficiency analysis of the 46D/E region has identified a lethal complementation group associated with reduced PFK activity, thereby establishing the vital role of PFK function in Drosophila [1].
Southern blots of genomic DNA, comparison of multiple clones, and in situ hybridization to salivary gland chromosomes indicate that the Drosophila genome contains a single copy of the gene which encodes phosphofructokinase (PFK) that is located at cytogenetic position 46D/E on the polytene map [1].
Phosphofructokinase (PFK;EC 2.7.1.11) activity in Drosophila melanogaster is controlled by a single dosage-sensitive region of the genome between 45F and 47E of chromosome IIR [2].

References

Structure and expression of the gene encoding phosphofructokinase (PFK) in Drosophila melanogaster. Currie, P.D., Sullivan, D.T. J. Biol. Chem. (1994) [Pubmed]
Genetic and biochemical characterization of phosphofructokinase from Drosophila melanogaster. Munneke, L.R., Collier, G.E. Biochem. Genet. (1985) [Pubmed]

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