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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Ppid  -  peptidylprolyl isomerase D

Rattus norvegicus

Synonyms: 40 kDa peptidyl-prolyl cis-trans isomerase, CYP-40, Cyclophilin-40, Cyp-40, CypD, ...
 
 
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Disease relevance of Ppid

  • Cyp-40 expression was markedly increased in adenomas from continuously exposed rats, but expression returned to levels similar to surrounding parenchyma in adenomas after 5 days of WY-14,643 withdrawal [1].
 

High impact information on Ppid

  • To determine cellular and molecular events responsible for enhanced growth in PP-induced liver tumors, we evaluated the relationships of WY-14,643 levels, apoptosis, mitosis and cyclophilin-40 (Cyp-40) expression in regressing tumors induced by WY-14,643, a potent PP [1].
  • Apoptosis, mitosis and cyclophilin-40 expression in regressing peroxisome proliferator-induced adenomas [1].
  • 3. It is suggested that the proposed interaction of matrix PPIase with the 'c' conformation of the adenine nucleotide carrier in the presence of Ca2+ [Griffiths & Halestrap (1991) Biochem. J. 274, 611-614] is inhibited by low pH [2].
  • 4. 2. The effect could not be explained by inhibition of Ca2+ uptake into the mitochondria, or of the matrix peptidyl-prolyl cis-trans isomerase (PPIase), or of the Ca(2+)-induced conformational change of the adenine nucleotide translocase [2].

References

  1. Apoptosis, mitosis and cyclophilin-40 expression in regressing peroxisome proliferator-induced adenomas. Miller, R.T., Anderson, S.P., Corton, J.C., Cattley, R.C. Carcinogenesis (2000) [Pubmed]
  2. Calcium-dependent opening of a non-specific pore in the mitochondrial inner membrane is inhibited at pH values below 7. Implications for the protective effect of low pH against chemical and hypoxic cell damage. Halestrap, A.P. Biochem. J. (1991) [Pubmed]
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