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Gene Review

inv  -  invected

Drosophila melanogaster

Synonyms: CG17835, Dmel\CG17835, Engrailed/Invected, Homeobox protein invected, IV, ...
 
 
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High impact information on inv

  • Thus establishment of the anterior-posterior organizer and control of compartment identity are genetically distinguishable, and invected may perform a discrete subset of functions previously ascribed to engrailed [1].
  • Like the engrailed gene, the invected gene can encode a protein of approximately 60 kD that contains a homeo box near its carboxyl terminus; indeed, a sequence of 117 amino acids in the carboxy-terminal region of both proteins is almost identical [2].
  • Expression of an engrailed-related protein is induced in the anterior neural ectoderm of early Xenopus embryos [3].
  • RESULTS: We have identified several transcription factors, including butterfly homologs of the Drosophila Engrailed/Invected and Spalt proteins, that are deployed in concentric territories corresponding to the future rings of pigmented scales that compose the adult eyespot [4].
  • The activities of the selector genes engrailed and invected in posterior cells and the transduction of the Hedgehog signal in anterior cells are required for maintaining the A/P boundary [5].
 

Biological context of inv

 

Anatomical context of inv

  • In embryos that lack the segmental tendon cells, due to a mutation removing the related segment polarity genes engrailed and invected, alphaPS2betaPS is still localized to the muscle termini even though the ventral longitudinal muscles are not attached to the epidermis, but instead are attached end to end [10].
 

Regulatory relationships of inv

  • Similarly, patched (ptc) is also ectopically expressed in such posterior compartment en-inv- null clones [11].
 

Other interactions of inv

  • Surprisingly, it was found that engrailed expression extended a small distance into the anterior lineage compartment of the wing blade, as identified with anti-en/inv mAb, anti-en polyclonal antiserum, or an en-promoter-lacZ insert, ryxho25 [12].
 

Analytical, diagnostic and therapeutic context of inv

References

  1. Distinguishable functions for engrailed and invected in anterior-posterior patterning in the Drosophila wing. Simmonds, A.J., Brook, W.J., Cohen, S.M., Bell, J.B. Nature (1995) [Pubmed]
  2. The invected gene of Drosophila: sequence analysis and expression studies reveal a close kinship to the engrailed gene. Coleman, K.G., Poole, S.J., Weir, M.P., Soeller, W.C., Kornberg, T. Genes Dev. (1987) [Pubmed]
  3. Expression of an engrailed-related protein is induced in the anterior neural ectoderm of early Xenopus embryos. Brivanlou, A.H., Harland, R.M. Development (1989) [Pubmed]
  4. The generation and diversification of butterfly eyespot color patterns. Brunetti, C.R., Selegue, J.E., Monteiro, A., French, V., Brakefield, P.M., Carroll, S.B. Curr. Biol. (2001) [Pubmed]
  5. The role of Dpp signaling in maintaining the Drosophila anteroposterior compartment boundary. Shen, J., Dahmann, C. Dev. Biol. (2005) [Pubmed]
  6. A Delta-Notch signaling border regulated by Engrailed/Invected repression specifies boundary cells in the Drosophila hindgut. Iwaki, D.D., Lengyel, J.A. Mech. Dev. (2002) [Pubmed]
  7. Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila. Blair, S.S., Ralston, A. Development (1997) [Pubmed]
  8. Wing development and specification of dorsal cell fates in the absence of apterous in Drosophila. Klein, T., Couso, J.P., Martinez Arias, A. Curr. Biol. (1998) [Pubmed]
  9. Genetic and molecular analysis of vgU and vgW: two dominant vg alleles associated with gene fusions in Drosophila. Williams, J.A., Scott, I.M., Atkin, A.L., Brook, W.J., Russell, M.A., Bell, J.B. Genetics (1990) [Pubmed]
  10. Intracellular signals direct integrin localization to sites of function in embryonic muscles. Martin-Bermudo, M.D., Brown, N.H. J. Cell Biol. (1996) [Pubmed]
  11. Drawing a stripe in Drosophila imaginal disks: negative regulation of decapentaplegic and patched expression by engrailed. Sanicola, M., Sekelsky, J., Elson, S., Gelbart, W.M. Genetics (1995) [Pubmed]
  12. Engrailed expression in the anterior lineage compartment of the developing wing blade of Drosophila. Blair, S.S. Development (1992) [Pubmed]
  13. Shell differentiation and engrailed expression in the Ilyanassa embryo. Moshel, S.M., Levine, M., Collier, J.R. Dev. Genes Evol. (1998) [Pubmed]
 
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