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Gene Review

Buffy  -  CG8238 gene product from transcript CG8238-RA

Drosophila melanogaster

Synonyms: BUFFY, Bcl-2-48AE, Buffy/Borg2, Buffy/DBorg-2, Buffy/dBorg-2, ...
 
 
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High impact information on Buffy

 

Other interactions of Buffy

  • Both pro-apoptotic and anti-apoptotic members of this family are found in mammalian cells, but only the pro-apoptotic protein Debcl has been characterized in Drosophila: Here we report that Buffy, the second Drosophila Bcl-2-like protein, is a pro-survival protein [2].

References

  1. Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila. Senoo-Matsuda, N., Igaki, T., Miura, M. EMBO J. (2005) [Pubmed]
  2. Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions. Quinn, L., Coombe, M., Mills, K., Daish, T., Colussi, P., Kumar, S., Richardson, H. EMBO J. (2003) [Pubmed]
 
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