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Gene Review:

NIK1 - histidine kinase osmosensor

Candida albicans SC5314

Li, D. et al., Kruppa, M. et al., Nagahashi, S. et al., Kruppa, M. et al.

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High impact information on CaO19.5181

In the sln1 mutant, downregulation of CHK1 was observed in all growth conditions compared to strain CAI4 (P < 0.05), while regulation of lacZ in the nik1 mutant was similar to strain CAI4 except when cells were incubated in the presence of 4 mM H2O2 for 120 min (P < 0.05) [1].
1. In addition to CHK1, two other histidine kinases (SLN1 and NIK1) have been described in C. albicans [2].
Here, we show that a C. albicans mutant lacking Chk1p but not either the Sln1p or the Nik1p histidine kinase is refractory to the inhibitory effect of farnesol both in cell suspension and during the formation of a biofilm [3].

Analytical, diagnostic and therapeutic context of CaO19.5181

Southern blotting with C. albicans SLN1 revealed the presence of related genes, one of which is highly homologous to the NIK1 gene of Neurospora crassa [4].

References

Studies on the regulation of the two-component histidine kinase gene CHK1 in Candida albicans using the heterologous lacZ reporter gene. Li, D., Gurkovska, V., Sheridan, M., Calderone, R., Chauhan, N. Microbiology (Reading, Engl.) (2004) [Pubmed]
The histidine kinases of Candida albicans: regulation of cell wall mannan biosynthesis. Kruppa, M., Jabra-Rizk, M.A., Meiller, T.F., Calderone, R. FEMS Yeast Res. (2004) [Pubmed]
The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans. Kruppa, M., Krom, B.P., Chauhan, N., Bambach, A.V., Cihlar, R.L., Calderone, R.A. Eukaryotic Cell (2004) [Pubmed]
Isolation of CaSLN1 and CaNIK1, the genes for osmosensing histidine kinase homologues, from the pathogenic fungus Candida albicans. Nagahashi, S., Mio, T., Ono, N., Yamada-Okabe, T., Arisawa, M., Bussey, H., Yamada-Okabe, H. Microbiology (Reading, Engl.) (1998) [Pubmed]

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