Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

iha - bifunctional enterobactin receptor/adhesin...

Escherichia coli

Johnson, J.R. et al., Schmidt, H. et al., Johnson, J.R. et al., Schaeffer, A.J., Bastos, F.C. et al.

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Disease relevance of iha

Molecular epidemiological and phylogenetic associations of two novel putative virulence genes, iha and iroN(E. coli), among Escherichia coli isolates from patients with urosepsis [1].
Fecal E. coli isolates exhibited significantly lower prevalences of iha (range, 14 to 22%) than did clinical isolates from cases of pediatric cystitis or pyelonephritis, adult pyelonephritis or urosepsis, or bacteremia (range, 38 to 74%) [2].

High impact information on iha

Molecular epidemiology of 3 putative virulence genes for Escherichia coli urinary tract infection--usp, iha, and iroN(E. coli) [3].
Despite differences in the stx genotypes, all strains carried eae-gamma, efa1, ehx, iha, lpf(O157) and toxB sequences [4].

Analytical, diagnostic and therapeutic context of iha

Using PCR analysis of various STEC, enteropathogenic E. coli, enterotoxigenic E. coli, enteroaggregative E. coli, uropathogenic E. coli, and enteroinvasive E. coli strains, we detected the iha homologue in 59 (62%) of 95 strains tested [5].

References

Molecular epidemiological and phylogenetic associations of two novel putative virulence genes, iha and iroN(E. coli), among Escherichia coli isolates from patients with urosepsis. Johnson, J.R., Russo, T.A., Tarr, P.I., Carlino, U., Bilge, S.S., Vary, J.C., Stell, A.L. Infect. Immun. (2000) [Pubmed]
The IrgA homologue adhesin Iha is an Escherichia coli virulence factor in murine urinary tract infection. Johnson, J.R., Jelacic, S., Schoening, L.M., Clabots, C., Shaikh, N., Mobley, H.L., Tarr, P.I. Infect. Immun. (2005) [Pubmed]
Molecular epidemiology of 3 putative virulence genes for Escherichia coli urinary tract infection--usp, iha, and iroN(E. coli). Schaeffer, A.J. J. Urol. (2003) [Pubmed]
Phenotypic characteristics, virulence profile and genetic relatedness of O157 Shiga toxin-producing Escherichia coli isolated in Brazil and other Latin American countries. Bastos, F.C., Vaz, T.M., Irino, K., Guth, B.E. FEMS Microbiol. Lett. (2006) [Pubmed]
Identification and characterization of a novel genomic island integrated at selC in locus of enterocyte effacement-negative, Shiga toxin-producing Escherichia coli. Schmidt, H., Zhang, W.L., Hemmrich, U., Jelacic, S., Brunder, W., Tarr, P.I., Dobrindt, U., Hacker, J., Karch, H. Infect. Immun. (2001) [Pubmed]

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