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Gene Review

Tb927.2.6000  -  glycosyl transferase

Trypanosoma brucei brucei TREU927

 
 
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Disease relevance of Tb927.2.6000

 

High impact information on Tb927.2.6000

 

Biological context of Tb927.2.6000

  • Together, these observations place Cys80 and Gln81 at, or close to, the active site of GPtdIns-PLC from T. brucei [6].
  • However, an effective response was restored upon reintegration of the GPI-PLC gene in the genome (PLC+) [7].
  • The relegation of short stumpy surface GPI-PLC to a secondary role in differentiation suggests that it may play a more important role as a virulence factor within the mammalian host [8].
  • Restriction enzyme fragments located to the 3' side of the T. cruzi hsp100 gene were then sequenced and found to contain a gene that encodes a polypeptide (TcPLC1) that has 46% amino acid sequence identity with the T. brucei GPI-PLC including most of the key residues involved in inositol binding and the catalytic histidine [9].
  • Conservation of genetic linkage between heat shock protein 100 and glycosylphosphatidylinositol-specific phospholipase C in Trypanosoma brucei and Trypanosoma cruzi [9].
 

Anatomical context of Tb927.2.6000

  • A catalytically inactive Gln81Leu mutant of GPI-PLC failed to cleave GPIs despite being transported from glycosomes to the ER after hypo-osmotic or mild alkaline treatment of the parasites [2].
 

Associations of Tb927.2.6000 with chemical compounds

References

  1. Acetylcholinesterases from Musca domestica and Drosophila melanogaster brain are linked to membranes by a glycophospholipid anchor sensitive to an endogenous phospholipase. Fournier, D., Bergé, J.B., Cardoso de Almeida, M.L., Bordier, C. J. Neurochem. (1988) [Pubmed]
  2. Regulated cleavage of intracellular glycosylphosphatidylinositol in a trypanosome. Subramanya, S., Mensa-Wilmot, K. FEBS J. (2006) [Pubmed]
  3. Surface coat remodeling during differentiation of Trypanosoma brucei. Gruszynski, A.E., DeMaster, A., Hooper, N.M., Bangs, J.D. J. Biol. Chem. (2003) [Pubmed]
  4. A role for the dynamic acylation of a cluster of cysteine residues in regulating the activity of the glycosylphosphatidylinositol-specific phospholipase C of Trypanosoma brucei. Paturiaux-Hanocq, F., Hanocq-Quertier, J., de Almeida, M.L., Nolan, D.P., Pays, A., Vanhamme, L., Van den Abbeele, J., Wasunna, C.L., Carrington, M., Pays, E. J. Biol. Chem. (2000) [Pubmed]
  5. Tetramerization of glycosylphosphatidylinositol-specific phospholipase C from Trypanosoma brucei. Armah, D.A., Mensa-Wilmot, K. J. Biol. Chem. (2000) [Pubmed]
  6. Roles of Gln81 and Cys80 in catalysis by glycosylphosphatidylinositol-phospholipase C from Trypanosoma brucei. Rashid, M.B., Russell, M., Mensa-Wilmot, K. Eur. J. Biochem. (1999) [Pubmed]
  7. Mild acid stress as a differentiation trigger in Trypanosoma brucei. Rolin, S., Hancocq-Quertier, J., Paturiaux-Hanocq, F., Nolan, D.P., Pays, E. Mol. Biochem. Parasitol. (1998) [Pubmed]
  8. Regulation of surface coat exchange by differentiating African trypanosomes. Gruszynski, A.E., van Deursen, F.J., Albareda, M.C., Best, A., Chaudhary, K., Cliffe, L.J., Del Rio, L., Dunn, J.D., Ellis, L., Evans, K.J., Figueiredo, J.M., Malmquist, N.A., Omosun, Y., Palenchar, J.B., Prickett, S., Punkosdy, G.A., van Dooren, G., Wang, Q., Menon, A.K., Matthews, K.R., Bangs, J.D. Mol. Biochem. Parasitol. (2006) [Pubmed]
  9. Conservation of genetic linkage between heat shock protein 100 and glycosylphosphatidylinositol-specific phospholipase C in Trypanosoma brucei and Trypanosoma cruzi. Redpath, M.B., Carnall, N., Webb, H., Courel, M., Amorim, A., Güther, M.L., Cardoso de Almeida, M.L., Carrington, M. Mol. Biochem. Parasitol. (1998) [Pubmed]
 
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