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Gene Review:

Tb10.6k15.3720 - acid phosphatase

Trypanosoma brucei brucei TREU927

Steiger, R.F. et al., Prado-Figueroa, M. et al., Engstler, M. et al., Walter, R.D. et al., Schell, D. et al.

Engstler, Weise, Bopp, Grünfelder, Günzel, Heddergott, Overath,

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High impact information on Tb10.6k15.3720

In this study we show that the type I membrane protein TbMBAP1, an L-(+)-tartrate-sensitive acid phosphatase, is present in all endosomal membranes but is virtually absent from the lysosome membrane (where this type of protein is mainly found in other organisms) and is not detectable at the cell surface [1].
Purification and characterization of a tartrate-sensitive acid phosphatase of Trypanosoma brucei [2].
Both constituents exhibited a shift towards lower densities after pre-treatment of microsomal membranes with inorganic pyrophosphate, while other membrane markers such as acid phosphatase and nucleoside diphosphatase did not [3].
The latter enzyme appeared to be absent from the plasma-membrane fraction but copurified with acid phosphatase and acid phosphodiesterase indicating a possible association with the flagellar pocket [4].
Similar results were obtained for acid phosphatase, acid phosphodiesterase and inosine diphosphatase [5].

Other interactions of Tb10.6k15.3720

Inosine diphosphatase, galactosyl transferase, acid phosphatase and acid phosphodiesterase sediment predominantly as microsomal constituents equilibrating at densities between 1.13 and 1.15 g/cm3 [5].

References

The membrane-bound histidine acid phosphatase TbMBAP1 is essential for endocytosis and membrane recycling in Trypanosoma brucei. Engstler, M., Weise, F., Bopp, K., Grünfelder, C.G., Günzel, M., Heddergott, N., Overath, P. J. Cell. Sci. (2005) [Pubmed]
Purification and characterization of a tartrate-sensitive acid phosphatase of Trypanosoma brucei. Schell, D., Stierhof, Y.D., Overath, P. FEBS Lett. (1990) [Pubmed]
Possible localisation of dolichol-dependent mannosyltransferase of Trypanosoma brucei to the rough endoplasmic reticulum. Prado-Figueroa, M., Raper, J., Opperdoes, F.R. Mol. Biochem. Parasitol. (1994) [Pubmed]
Subcellular distribution of adenylate cyclase, cyclic-AMP phosphodiesterase, protein kinases and phosphoprotein phosphatase in Trypanosoma brucei. Walter, R.D., Opperdoes, F.R. Mol. Biochem. Parasitol. (1982) [Pubmed]
Subcellular fractionation of Trypanosoma brucei bloodstream forms with special reference to hydrolases. Steiger, R.F., Opperdoes, F.R., Bontemps, J. Eur. J. Biochem. (1980) [Pubmed]

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