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Rac2  -  ras-related C3 botulinum toxin substrate 2...

Rattus norvegicus

 
 
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High impact information on Rac2

  • We show here that the extension of neurites induced by nerve growth factor (NGF) in the neuronal cell line PC12 is inhibited by dominant-negative Rac2 and Cdc42, indicating that these GTPases are required components of the NGF signaling pathway [1].
  • Rac1 and Rac2 are also essential components of NADPH oxidase, the enzyme responsible for generating free radicals [2].

References

  1. Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. Daniels, R.H., Hall, P.S., Bokoch, G.M. EMBO J. (1998) [Pubmed]
  2. Rac-GTPase, osteoclast cytoskeleton and bone resorption. Razzouk, S., Lieberherr, M., Cournot, G. Eur. J. Cell Biol. (1999) [Pubmed]
 
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