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Gene Review:

Nup62 - Nucleoporin 62kD

Drosophila melanogaster

Synonyms: CG6251, Dmel\CG6251, p62

Uv, A.E. et al., Onischenko, E.A. et al., Kiger, A.A. et al., Roth, P. et al., Gigliotti, S. et al.

Gigliotti, Callaini, Andone, Riparbelli, Pernas-Alonso, Hoffmann, Graziani, Malva,

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High impact information on Nup62

members only encodes a Drosophila nucleoporin required for rel protein import and immune response activation [1].
Here we describe the Drosophila gene members only (mbo) encoding a nucleoporin homologous to the mammalian Nup88 [1].
The Drosophila nucleoporin DNup88 localizes DNup214 and CRM1 on the nuclear envelope and attenuates NES-mediated nuclear export [2].
Nup154, a new Drosophila gene essential for male and female gametogenesis is related to the nup155 vertebrate nucleoporin gene [3].
Developmental genetics of the essential Drosophila nucleoporin nup154: allelic differences due to an outward-directed promoter in the P-element 3' end [4].

Biological context of Nup62

However, even during interphases, only a small fraction of the excess nucleoporins was assembled into ALPCs, whereas the major fraction was soluble and contained at least one phosphorylated nucleoporin [5].

References

members only encodes a Drosophila nucleoporin required for rel protein import and immune response activation. Uv, A.E., Roth, P., Xylourgidis, N., Wickberg, A., Cantera, R., Samakovlis, C. Genes Dev. (2000) [Pubmed]
The Drosophila nucleoporin DNup88 localizes DNup214 and CRM1 on the nuclear envelope and attenuates NES-mediated nuclear export. Roth, P., Xylourgidis, N., Sabri, N., Uv, A., Fornerod, M., Samakovlis, C. J. Cell Biol. (2003) [Pubmed]
Nup154, a new Drosophila gene essential for male and female gametogenesis is related to the nup155 vertebrate nucleoporin gene. Gigliotti, S., Callaini, G., Andone, S., Riparbelli, M.G., Pernas-Alonso, R., Hoffmann, G., Graziani, F., Malva, C. J. Cell Biol. (1998) [Pubmed]
Developmental genetics of the essential Drosophila nucleoporin nup154: allelic differences due to an outward-directed promoter in the P-element 3' end. Kiger, A.A., Gigliotti, S., Fuller, M.T. Genetics (1999) [Pubmed]
Annulate lamellae play only a minor role in the storage of excess nucleoporins in Drosophila embryos. Onischenko, E.A., Gubanova, N.V., Kieselbach, T., Kiseleva, E.V., Hallberg, E. Traffic (2004) [Pubmed]

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