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ITIH2  -  inter-alpha-trypsin inhibitor heavy chain 2

Homo sapiens

Synonyms: H2P, IGHEP2, ITI heavy chain H2, ITI-HC2, Inter-alpha-inhibitor heavy chain 2, ...
 
 
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High impact information on ITIH2

  • SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum [1].
  • Leukocytes infiltrated to the synovium were strongly positive for HA, SHAP, and CD44 on their surfaces, suggesting a role for the adhesion-enhancing effect of SHAP in pathogenesis [1].
  • We therefore examined the effect of SHAP on the CD44-HA interaction-mediated lymphocyte adhesion [1].
  • Two RFLPs in human inter-alpha-trypsin inhibitor heavy chain gene ITIH2 on chromosome 10 [2].
  • The results show that the Rac signaling pathway is activated in the metastatic HCC cell line (H2M) compared with the primary HCC cell line (H2P) [3].
 

Anatomical context of ITIH2

References

  1. SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum. Zhuo, L., Kanamori, A., Kannagi, R., Itano, N., Wu, J., Hamaguchi, M., Ishiguro, N., Kimata, K. J. Biol. Chem. (2006) [Pubmed]
  2. Two RFLPs in human inter-alpha-trypsin inhibitor heavy chain gene ITIH2 on chromosome 10. Léveillard, T., Bourguignon, J., Salier, J.P., Diarra-Mehrpour, M., Sesboüé, R., Martin, J.P. Nucleic Acids Res. (1989) [Pubmed]
  3. Significance of the Rac signaling pathway in HCC cell motility: implications for a new therapeutic target. Lee, T.K., Man, K., Ho, J.W., Wang, X.H., Poon, R.T., Sun, C.K., Ng, K.T., Ng, I.O., Xu, R., Fan, S.T. Carcinogenesis (2005) [Pubmed]
  4. Genetic analysis of IgE and the IGHE, IGHEP1 and IGHEP2 genes in atopic families. Fujii, H., Kondo, N., Agata, H., Fukutomi, O., Shinoda, S., Kuwabara, N., Tomatsu, S., Kondo, T., Inoue, R., Orii, T. Int. Arch. Allergy Immunol. (1995) [Pubmed]
 
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