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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

H4L  -  temporal expression: late

Vaccinia virus

 
 
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Disease relevance of H4L

  • Peptide sequencing established that the RNA polymerase-associated 85-kDa protein was derived from the vaccinia virus H4L open reading frame, which encodes a 94-kDa polypeptide that we named RAP94 [1].
  • Unlike the previously defined subunits of vaccinia virus RNA polymerase, RAP94 is synthesized exclusively late in infection, and synthesis could be prevented by a DNA replication inhibitor [1].
  • The association of a 94,000-Da viral polypeptide, called Rap94, with 30-40% of the multisubunit DNA-dependent RNA polymerase molecules purified from infectious vaccinia virus particles was established by immunoaffinity chromatography [2].
 

High impact information on H4L

 

Biological context of H4L

  • A functional preinitiation transcription complex was formed by incubating vaccinia virus early transcription factor VETF and RAP94+ RNA polymerase with an early promoter template immobilized on paramagnetic particles [3].

References

  1. RNA polymerase-associated transcription specificity factor encoded by vaccinia virus. Ahn, B.Y., Moss, B. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. RNA polymerase-associated protein Rap94 confers promoter specificity for initiating transcription of vaccinia virus early stage genes. Ahn, B.Y., Gershon, P.D., Moss, B. J. Biol. Chem. (1994) [Pubmed]
  3. Ordered assembly of a functional preinitiation transcription complex, containing vaccinia virus early transcription factor and RNA polymerase, on an immobilized template. Baldick, C.J., Cassetti, M.C., Harris, N., Moss, B. J. Virol. (1994) [Pubmed]
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