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Gene Review:

K3L - temporal expression: early

Vaccinia virus

Liu, Y. et al., McInnes, C.J. et al., Jacobs, B.L. et al., Davies, M.V. et al., Haig, D.M. et al., et al.

Jacobs, Langland, Brandt, McInnes, Wood, Mercer,

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Disease relevance of K3L

Both carboxy- and amino-terminal domains of the vaccinia virus interferon resistance gene, E3L, are required for pathogenesis in a mouse model [1].
The orf virus OV20.0L gene product is involved in interferon resistance and inhibits an interferon-inducible, double-stranded RNA-dependent kinase [2].
Orf virus encodes a homolog of the vaccinia virus interferon-resistance gene E3L [3].
A homolog of the vaccinia virus (VAC) interferon resistance gene E3L has been discovered in orf virus strain NZ-2, a parapoxvirus that infects sheep, goats and humans [3].

High impact information on K3L

Replication of modified vaccinia virus Ankara in primary chicken embryo fibroblasts requires expression of the interferon resistance gene E3L [4].
We have studied the mechanism by which this protein product elicits interferon resistance in a transient DNA transfection system designed to evaluate regulators of eIF-2 alpha phosphorylation [5].
These results demonstrate that the A-to-I RNA editing activity of the IFN-inducible adenosine deaminase is impaired by the product of the vaccinia virus E3L interferon resistance gene [6].
These proteins have been implicated in providing interferon resistance to viruses and in inhibiting induction of apoptosis by viruses, and have been suggested to be involved in regulation of viral and cellular protein synthesis in infected cells [7].

Chemical compound and disease context of K3L

Vaccinia virus E3L interferon resistance protein inhibits the interferon-induced adenosine deaminase A-to-I editing activity [6].

Biological context of K3L

The OVIFNR gene at the left terminus of the viral genome encodes an interferon resistance protein with homology to the E3L gene of vaccinia virus [8].

References

Both carboxy- and amino-terminal domains of the vaccinia virus interferon resistance gene, E3L, are required for pathogenesis in a mouse model. Brandt, T.A., Jacobs, B.L. J. Virol. (2001) [Pubmed]
The orf virus OV20.0L gene product is involved in interferon resistance and inhibits an interferon-inducible, double-stranded RNA-dependent kinase. Haig, D.M., McInnes, C.J., Thomson, J., Wood, A., Bunyan, K., Mercer, A. Immunology (1998) [Pubmed]
Orf virus encodes a homolog of the vaccinia virus interferon-resistance gene E3L. McInnes, C.J., Wood, A.R., Mercer, A.A. Virus Genes (1998) [Pubmed]
Replication of modified vaccinia virus Ankara in primary chicken embryo fibroblasts requires expression of the interferon resistance gene E3L. Hornemann, S., Harlin, O., Staib, C., Kisling, S., Erfle, V., Kaspers, B., Häcker, G., Sutter, G. J. Virol. (2003) [Pubmed]
The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2. Davies, M.V., Elroy-Stein, O., Jagus, R., Moss, B., Kaufman, R.J. J. Virol. (1992) [Pubmed]
Vaccinia virus E3L interferon resistance protein inhibits the interferon-induced adenosine deaminase A-to-I editing activity. Liu, Y., Wolff, K.C., Jacobs, B.L., Samuel, C.E. Virology (2001) [Pubmed]
Characterization of viral double-stranded RNA-binding proteins. Jacobs, B.L., Langland, J.O., Brandt, T. Methods (1998) [Pubmed]
Immunomodulation by virulence proteins of the parapoxvirus orf virus. Haig, D.M., Fleming, S. Vet. Immunol. Immunopathol. (1999) [Pubmed]

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