High impact information on fj

• We show that two cadherin superfamily members, Fat and Dachsous, and the transmembrane/secreted protein Four-jointed play important roles in this process [1].
• We show that fj interacts genetically with ft and ds in planar polarity and proximodistal patterning [2].
• Both fat and Atrophin are required to control four-jointed expression [3].
• The similarities between four-jointed and Notch phenotypes led us to further investigate the relationships between these pathways [4].
• Thus, four-jointed may bridge the gap between the signals that direct morphogenesis and those that carry it out [4].

Biological context of fj

• Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression [5].
• Analysis of the fj phenotype and expression pattern in the leg suggests that fj is required for cell-cell signaling during disc development [6].
• Dependence of bristle pattern on size and joint formation was studied for male first leg tarsi of fj (four jointed) and d (dachs) mutants in homozygotes and in mosaics resulting from X-ray induced mitotic recombination [7].
• For instance, expression of at least one reporter transgene was shown to correlate with that of the endogenous gene in the case of insertions in Ultrabithorax, four-jointed, and the iroquois complex [8].

Anatomical context of fj

• Consistent with a position-sensitive role, we show that fj is expressed in a regional pattern in the developing leg, wing, eye and optic lobe [9].

Associations of fj with chemical compounds

• The fj gene encodes a novel type II membrane glycoprotein [9].

Regulatory relationships of fj

• Ectopic expression of DWnt4 in the dorsoventral (DV) polar margins is insufficient to induce ommatidial polarity but becomes inductive when coexpressed with Four-jointed (Fj) [10].

Other interactions of fj

• Control of planar cell polarity by interaction of DWnt4 and four-jointed [10].

References