Gene Review:
SUMO1 - SMT3 suppressor of mif two 3 homolog 1 (S....
Gallus gallus
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High impact information on SUMO1
- A considerable portion of the Ubc9-depleted cell population was committed to apoptosis without accumulating in a specific phase of the cell cycle, suggesting that chromosome damages are accumulated in Ubc9-depleted cells, and apoptosis is triggered without activating checkpoint mechanisms under conditions of SUMO-1 conjugation system impairment [1].
- To determine the physiological roles of SUMO-1 conjugation in higher eukaryotic cells, we constructed a conditional UBC9 mutant of chicken DT40 cells containing the UBC9 transgene under control of a tetracycline-repressible promoter and characterized their loss of function phenotypes [1].
References
- Ubc9 is essential for viability of higher eukaryotic cells. Hayashi, T., Seki, M., Maeda, D., Wang, W., Kawabe, Y., Seki, T., Saitoh, H., Fukagawa, T., Yagi, H., Enomoto, T. Exp. Cell Res. (2002) [Pubmed]
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