Gene Review:
FBLN1 - fibulin 1
Gallus gallus
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High impact information on FBLN1
- We also describe identification of a C. elegans cDNA encoding fibulin-1D and cosmids containing the C. elegans fibulin-1 gene [1].
- The C. elegans fibulin-1 gene is located on chromosome IV, is approximately 6 kb in length, contains 16 exons and encodes fibulin-1C and D variants [1].
- Fibulin-1, a member of the emerging family of fibulin proteins, is a component of elastic extracellular matrix fibers, basement membranes and blood [1].
- Comparative analysis of the deduced amino acid sequences of nematode and chicken fibulin-1 variants with other known vertebrate fibulin-1 polypeptides showed that the number and organization of structural modules are identical [1].
Analytical, diagnostic and therapeutic context of FBLN1
- Using the cDNA, RT-PCR and computer-based analysis of genomic sequences, the exon/intron organization of the C. elegans fibulin-1 gene was determined [1].
References
- Identification of chicken and C. elegans fibulin-1 homologs and characterization of the C. elegans fibulin-1 gene. Barth, J.L., Argraves, K.M., Roark, E.F., Little, C.D., Argraves, W.S. Matrix Biol. (1998) [Pubmed]
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