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Gene Review

LMBR1  -  limb region 1 homolog (mouse)

Gallus gallus

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High impact information on LMBR1

  • Single nucleotide polymorphisms in the chicken Lmbr1 gene are associated with chicken polydactyly [1].
  • To understand the molecular mechanism underlying chicken polydactyly, we have cloned the open reading frame (ORF) of chicken Lmbr1, which contains 1467 nucleotides [1].
  • Radiation hybrid mapping of a DNA fragment containing intron 13 of the chicken Lmbr1 assigned the gene to chromosome 2 between MCW071 (a marker within the EN2 gene) and ADL0270, a syntenic region to human 7q36 [1].
  • The ozd phenotype is similar to that of humans affected with acheiropodia (ACHR), and the ACHR mutation has been mapped to a deletion of exon 4 and portions of introns 3 and 4 in the LMBR1 gene [2].
  • T/C and G/A mutations located in exon 16 and one A/C mutation located in intron 5 of chicken lmbr1 were detected from Silky, White Plymouth Rock broilers and their F(2) crossing chickens by PCR-SSCP and sequencing methods [3].


  1. Single nucleotide polymorphisms in the chicken Lmbr1 gene are associated with chicken polydactyly. Huang, Y.Q., Deng, X.M., Du, Z.Q., Qiu, X., Du, X., Chen, W., Morisson, M., Leroux, S., Ponce de Léon, F.A., Da, Y., Li, N. Gene (2006) [Pubmed]
  2. Isolation of the chicken Lmbr1 coding sequence and characterization of its role during chick limb development. Maas, S.A., Fallon, J.F. Dev. Dyn. (2004) [Pubmed]
  3. Single nucleotide polymorphisms in chicken lmbr1 gene were associated with chicken growth and carcass traits. Huang, Y., Du, X., Deng, X., Qiu, X., Wang, C., Chen, W., Li, N., Wu, C. Sci. China, C, Life Sci. (2007) [Pubmed]
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