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Gene Review

mago  -  mago nashi

Drosophila melanogaster

Synonyms: CG9401, Dm MGN, DmMago, Dmel\CG9401, MAGOH, ...
 
 
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High impact information on mago

  • Crystal structure of the Drosophila Mago nashi-Y14 complex [1].
  • Mago Nashi protein interprets the posterior follicle cell-to-oocyte signal to establish the major axes and to determine the fate of the primordial germ cells [2].
  • In the absence of mago+ function during oogenesis, the anteroposterior and dorsoventral coordinates of the oocyte are not specified and the germ plasm fails to assemble [3].
  • Its posterior transport along the microtubules is mediated by Kinesin I and several proteins, such as Mago-nashi, which, together with oskar mRNA, form a posterior localization complex [4].
  • RESULTS: In addition to its previously described role in the localisation of oskar mRNA, the mago nashi gene is required in the germ line for the transduction of the polarising signal from the posterior follicle cells [5].
 

Biological context of mago

  • In a search for zebrafish genes expressed during early stages of development, we have identified two ESTs encoding proteins related to Drosophila mago nashi [6].
  • The highly conserved amino acid sequence of all Mago Nashi protein homologs across kingdoms suggests that the plant version of this protein may similarly be involved in RNA localization [7].
  • Here we report the nucleotide sequence of a cDNA and a partial gene that encode rice Mago Nashi protein homologs [7].
  • Genomic DNA gel blot analysis indicates that two copies of the mago nashi gene exist in the rice genome, one of which has identical intron positions to those found in an Arabidopsis homolog. mago nashi is expressed in root, leaf and developing seed tissue as determined by RNA and protein gel blot analysis [7].
 

Anatomical context of mago

  • CONCLUSIONS: The mago nashi gene plays two essential roles in Drosophila axis formation: it is required downstream of the signal from the posterior follicle cells for the polarisation of the oocyte microtubule cytoskeleton, and has a second, independent role in the localisation of oskar mRNA to the posterior of the oocyte [5].
  • We show that a putative microtubule-mediated transport of mago nashi mRNA from the vegetal hemisphere into animal blastomeres determines the localization of the transcript in the animal pole, immediately after fertilization [6].
  • Our results demonstrate that mago nashi encodes a maternal transcript detected in both blastomeres and yolk cell at the 1-2 cell stages, and in the blastoderm during segmentation [6].
 

Physical interactions of mago

 

Other interactions of mago

  • These results show that a Mago Nashi-Tsunagi protein complex is required for interpreting the posterior follicle cell-to-oocyte signal to define the major body axes and to localize components necessary for determination of the primordial germ cells [2].
  • Using a new in vivo marker for microtubules, we show that mago nashi mutant oocytes develop a symmetric microtubule cytoskeleton that leads to the transient localisation of bicoid mRNA to both poles [5].

References

  1. Crystal structure of the Drosophila Mago nashi-Y14 complex. Shi, H., Xu, R.M. Genes Dev. (2003) [Pubmed]
  2. The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosophila oogenesis. Mohr, S.E., Dillon, S.T., Boswell, R.E. Genes Dev. (2001) [Pubmed]
  3. mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila. Newmark, P.A., Mohr, S.E., Gong, L., Boswell, R.E. Development (1997) [Pubmed]
  4. Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport. Hachet, O., Ephrussi, A. Curr. Biol. (2001) [Pubmed]
  5. The mago nashi gene is required for the polarisation of the oocyte and the formation of perpendicular axes in Drosophila. Micklem, D.R., Dasgupta, R., Elliott, H., Gergely, F., Davidson, C., Brand, A., González-Reyes, A., St Johnston, D. Curr. Biol. (1997) [Pubmed]
  6. Identification and expression pattern of mago nashi during zebrafish development. Pozzoli, O., Gilardelli, C.N., Sordino, P., Doniselli, S., Lamia, C.L., Cotelli, F. Gene Expr. Patterns (2004) [Pubmed]
  7. Molecular characterization and expression analysis of a highly conserved rice mago nashil homolog. Swidzinski, J.A., Zaplachinski, S.T., Chuong, S.D., Wong, J.F., Muench, D.G. Genome (2001) [Pubmed]
 
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