High impact information on CRY2

• Chickens' Cry2: molecular analysis of an avian cryptochrome in retinal and pineal photoreceptors [1].
• CRYPalpha and CRYP-2 mRNAs in contrast are expressed throughout the retinal ganglion cell layer from where axons grow out to their tectal targets [2].
• CRYPalpha, CRYP-2, and PTPmu proteins are also localized in growth cones of retinal ganglion cell axons and are present in defined laminae of the tectum [2].
• The cloning, expression, purification and crystallization of the catalytic domain of CRYP-2 are now reported [3].
• The receptor protein tyrosine phosphatase CRYP-2 has been shown to be an inhibitory factor for the growth of retinal axons in the chick [3].

Other interactions of CRY2

• The extracellular receptor domain of CRYP-2 contains eight fibronectin repeats and studies using the extracellular domain alone demonstrated the chemorepulsive effect on retinal neurons [3].

Analytical, diagnostic and therapeutic context of CRY2

• Using both in situ hybridization analysis and immunohistochemistry, we show for the first time that five RPTP genes--CRYPalpha, CRYP-2, PTPmu, PTPgamma, and PTPalpha--have different but overlapping expression patterns throughout the retina and the tectum [2].

References