Disease relevance of LITAF

• We conclude that chicken LITAF may play an important role in the regulation of TNF-alpha gene expression during the course of coccidiosis or tumorigenesis [1].
• Purified recombinant LITAF protein expressed in E. coli or COS7 cells exhibited cytotoxic activity against chicken tumor cell lines in vitro, presumably through autocrine activation of TNF-alpha or its chicken homologue [1].
• Also, the use of Oxoid SPRINT (Simple Pre-enrichment and Rapid Isolation New Technology) as a pre-enrichment and selective medium for 26-h BEIA detection of Salmonella in chicken meat samples was examined [2].

High impact information on LITAF

• This supposition was strengthened by the fact that treatment of chicken macrophages with recombinant LITAF induced the expression of TL1A (TNFSF 15), a member of the TNF ligand super family [1].
• In the current study, we isolated a full-length cDNA encoding the chicken homologue of LPS-induced TNF-alpha factor (LITAF), transcription factor, with an open reading frame of 148 amino acids and a predicted molecular mass of 16.0kDa [1].
• Quantitative RT-PCR analysis showed that chicken LITAF mRNA was predominantly expressed in spleen and intestinal intraepithelial lymphocytes (IELs) [1].
• 4. Simple air-conditioning can reduce the temperature sufficiently for the viability of the embryo to be preserved for up to a week [3].

Anatomical context of LITAF

• LITAF mRNA levels were up-regulated following in vitro stimulation of macrophages for 4 h with Escherichia coli or Salmonella typhimurium endotoxin, and 18-48 h after treatment with Eimeria acervulina, E. maxima, or E. tenella, three causative agents of avian coccidiosis [1].

Analytical, diagnostic and therapeutic context of LITAF

• Molecular cloning and characterization of chicken lipopolysaccharide-induced TNF-alpha factor (LITAF) [1].

References