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JAK2  -  Janus kinase 2

Gallus gallus

 
 
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Disease relevance of JAK2

  • In this study, GH-responsive, JAK2 immunoreactive proteins were first assessed in an avian hepatoma cell line (LMH) [1].
 

High impact information on JAK2

  • These findings indicate that PRL-mediated stimulation of c-Src was independent of Jak2 activation and of receptor phosphorylation [2].
  • At a dose of GH that was previously demonstrated to elicit a maximal metabolic response (6.25 microg/kg BW), maximum tyrosine phosphorylation of JAK2 appeared at 10 min post-GH administration in the pectoralis muscle, but was not detectable in liver [1].
  • Regulation of JAK2 protein expression by chronic, pulsatile GH administration in vivo: a possible mechanism for ligand enhancement of signal transduction [1].
  • We now report that GM-CSF in vivo induces angiogenesis and activates JAK-2 and signal transducers and activators of transcription (STAT)-3 [3].
 

Biological context of JAK2

 

Other interactions of JAK2

References

  1. Regulation of JAK2 protein expression by chronic, pulsatile GH administration in vivo: a possible mechanism for ligand enhancement of signal transduction. Zhou, Y., Wang, X., Hadley, J., Corey, S.J., Vasilatos-Younken, R. Gen. Comp. Endocrinol. (2005) [Pubmed]
  2. Stimulation of c-Src by prolactin is independent of Jak2. Fresno Vara, J.A., Carretero, M.V., Gerónimo, H., Ballmer-Hofer, K., Martín-Pérez, J. Biochem. J. (2000) [Pubmed]
  3. In vivo activation of JAK2/STAT-3 pathway during angiogenesis induced by GM-CSF. Valdembri, D., Serini, G., Vacca, A., Ribatti, D., Bussolino, F. FASEB J. (2002) [Pubmed]
 
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