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Gene Review:

LSP1 - lymphocyte-specific protein 1

Gallus gallus

Shira, E.B. et al., Gärtner, T. et al., Chow, L.M. et al., Horie, M. et al.

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Disease relevance of LSP1

These results suggest that MATSA may be a lymphocyte-specific antigen modified during leukemogenesis by Marek's disease virus (MDV) [1].

High impact information on LSP1

We have tested the possibility that tkl, a partially characterized avian tyrosine protein kinase gene, is the chicken homolog of lck, a lymphocyte-specific mammalian gene [2].
The tkl gene product may represent the avian homolog of Lck, which is believed to participate in a lymphocyte-specific signal transduction pathway by association with a membrane receptor [3].
GALT activity was determined by antibody production (systemic and locally in the gut), distribution of B and T lymphocytes in the gut, expression of lymphocyte specific genes, and distribution of B and T lymphocytes in the cloacal bursa [4].

References

Analysis of Marek's disease tumor-associated surface antigen on MDCC-MSB1-clo.18 cells. Horie, M., Ohashi, K., Kodama, H., Mikami, T. Int. J. Cancer (1991) [Pubmed]
tkl is the avian homolog of the mammalian lck tyrosine protein kinase gene. Chow, L.M., Ratcliffe, M.J., Veillette, A. Mol. Cell. Biol. (1992) [Pubmed]
A strong protein-tyrosine kinase activity is associated with a baculovirus-expressed chicken tkl gene. Gärtner, T., Kühnel, H., Raab, G., Raab, M., Strebhardt, K., Rübsamen-Waigmann, H. Eur. J. Biochem. (1992) [Pubmed]
Impaired immune responses in broiler hatchling hindgut following delayed access to feed. Shira, E.B., Sklan, D., Friedman, A. Vet. Immunol. Immunopathol. (2005) [Pubmed]

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