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Gene Review

mei-S332  -  meiotic from via Salaria 332

Drosophila melanogaster

Synonyms: BEST:LD13774, CG5303, Dmel\CG5303, MEI-S322, MEI-S332, ...
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Disease relevance of mei-S332


High impact information on mei-S332


Biological context of mei-S332

  • Previously isolated mutations in Drosophila specifically affect meiosis either in females or males, with the exception of the mei-S332 and ord genes which are required for proper sister-chromatid cohesion [4].
  • Analysis of sex chromosome segregation in the double mutant indicates that ord is epistatic to mei-S332 [5].
  • In mei-S332 mutants the ratio of metaphase to anaphase figures is lower than wild type, but it is higher if MEI-S332 is overexpressed [6].
  • Sister chromatid associations in mei-S332 are generally normal during prophase I and metaphare I [7].
  • All of the alleles are fully viable when in trans to a deficiency, thus mei-S332 is not essential for mitosis [8].

Anatomical context of mei-S332


Physical interactions of mei-S332


Enzymatic interactions of mei-S332


Regulatory relationships of mei-S332


Other interactions of mei-S332


  1. Cytogenetic analysis of homozygous segregation distorter males of Drosophila melanogaster. Erickson, J., Hartl, D.L. Can. J. Genet. Cytol. (1976) [Pubmed]
  2. Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Salic, A., Waters, J.C., Mitchison, T.J. Cell (2004) [Pubmed]
  3. Mei-S332, a Drosophila protein required for sister-chromatid cohesion, can localize to meiotic centromere regions. Kerrebrock, A.W., Moore, D.P., Wu, J.S., Orr-Weaver, T.L. Cell (1995) [Pubmed]
  4. Double or nothing: a Drosophila mutation affecting meiotic chromosome segregation in both females and males. Moore, D.P., Miyazaki, W.Y., Tomkiel, J.E., Orr-Weaver, T.L. Genetics (1994) [Pubmed]
  5. Genetic interactions between mei-S332 and ord in the control of sister-chromatid cohesion. Bickel, S.E., Moore, D.P., Lai, C., Orr-Weaver, T.L. Genetics (1998) [Pubmed]
  6. The mitotic centromeric protein MEI-S332 and its role in sister-chromatid cohesion. LeBlanc, H.N., Tang, T.T., Wu, J.S., Orr-Weaver, T.L. Chromosoma (1999) [Pubmed]
  7. Mechanisms of chromosome orientation revealed by two meiotic mutants in Drosophila melanogaster. Goldstein, L.S. Chromosoma (1980) [Pubmed]
  8. The Drosophila mei-S332 gene promotes sister-chromatid cohesion in meiosis following kinetochore differentiation. Kerrebrock, A.W., Miyazaki, W.Y., Birnby, D., Orr-Weaver, T.L. Genetics (1992) [Pubmed]
  9. Maintenance of sister-chromatid cohesion at the centromere by the Drosophila MEI-S332 protein. Tang, T.T., Bickel, S.E., Young, L.M., Orr-Weaver, T.L. Genes Dev. (1998) [Pubmed]
  10. INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila. Resnick, T.D., Satinover, D.L., MacIsaac, F., Stukenberg, P.T., Earnshaw, W.C., Orr-Weaver, T.L., Carmena, M. Dev. Cell (2006) [Pubmed]
  11. Drosophila cohesins DSA1 and Drad21 persist and colocalize along the centromeric heterochromatin during mitosis. Valdeolmillos, A., Rufas, J.S., Suja, J.A., Vass, S., Heck, M.M., Martínez-A, C., Barbero, J.L. Biol. Cell (2004) [Pubmed]
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