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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Fib  -  Fibrillarin

Drosophila melanogaster

Synonyms: CG9888, Dmel\CG9888, Fibri, GCR-6, GCR6, ...
 
 
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High impact information on Fib

  • U85 small CB-specific RNA, U2 small nuclear RNA, the survival of motor neurons protein, and fibrillarin occur together in a nuclear body that is closely associated with the nucleolus [1].
  • In eukaryotes, two distinct classes of small nucleolar RNAs (snoRNAs), namely the fibrillarin-associated box C/D snoRNAs and the Gar1p-associated box H/ACA snoRNAs, direct the site-specific 2'-O-ribose methylation and pseudouridylation of ribosomal RNAs (rRNAs), respectively [2].
  • In sle mutant neuroblasts, the nucleolus was packed more tightly, forming a dense sphere, and the nucleolar proteins fibrillarin and Nop60B were abnormally distributed in the interphase nucleolus [3].

References

  1. The Drosophila melanogaster Cajal body. Liu, J.L., Murphy, C., Buszczak, M., Clatterbuck, S., Goodman, R., Gall, J.G. J. Cell Biol. (2006) [Pubmed]
  2. A small nucleolar guide RNA functions both in 2'-O-ribose methylation and pseudouridylation of the U5 spliceosomal RNA. Jády, B.E., Kiss, T. EMBO J. (2001) [Pubmed]
  3. The slender lobes gene, identified by retarded mushroom body development, is required for proper nucleolar organization in Drosophila. Orihara-Ono, M., Suzuki, E., Saito, M., Yoda, Y., Aigaki, T., Hama, C. Dev. Biol. (2005) [Pubmed]
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