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Gene Review:

BFLF2 - BFLF2 protein

Human herpesvirus 4

Gonnella, R. et al., Nicholas, J. et al.

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Disease relevance of BFLF2

BFLF2 is an early transcript and is expressed in a variety of cell lines upon EBV lytic cycle activation [1].
Western blotting of purified virion preparations showed that BFLF2 is a component of intracellular virions but is absent from mature extracellular virions [1].

High impact information on BFLF2

Coimmunoprecipitation experiments indicated that BFLF2 interacts with BFRF1, which was confirmed by immunofluorescence confocal microscopy showing that the two proteins colocalize on the nuclear membrane not only upon cotransfection in epithelial cells but also during viral replication [1].
Furthermore, recomplementing the 293-BFRF1-KO cells by BFRF1 transfection restored BFLF2 expression to the wild-type level [1].
Characterization and intracellular localization of the Epstein-Barr virus protein BFLF2: interactions with BFRF1 and with the nuclear lamina [1].
The subsequent 18 genes in EBV (BFLF2 to BLRF2, approximate positions 56,000-89,500) are represented in HVS, and the relative positions and orientations of these genes are directly comparable between the two viruses [2].

References

Characterization and intracellular localization of the Epstein-Barr virus protein BFLF2: interactions with BFRF1 and with the nuclear lamina. Gonnella, R., Farina, A., Santarelli, R., Raffa, S., Feederle, R., Bei, R., Granato, M., Modesti, A., Frati, L., Delecluse, H.J., Torrisi, M.R., Angeloni, A., Faggioni, A. J. Virol. (2005) [Pubmed]
Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri (HVS) L-DNA: general conservation of genetic organization between HVS and Epstein-Barr virus. Nicholas, J., Cameron, K.R., Coleman, H., Newman, C., Honess, R.W. Virology (1992) [Pubmed]

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