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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Nanos2  -  nanos homolog 2 (Drosophila)

Mus musculus

Synonyms: NOS-2, Nanos homolog 2, Nos2, nos2
 
 
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High impact information on Nanos2

  • The mouse Nanos proteins, Nanos2 and Nanos3, are required for germ cell development and share a highly conserved zinc-finger domain [1].
  • Functional redundancy among Nanos proteins and a distinct role of Nanos2 during male germ cell development [1].
  • To determine whether Tlr4 modulates Nos2 mRNA levels, we studied C3H/HeJ (HeJ) and C3H/HeOuJ mice that differ only at a missense mutation in Tlr4 that confers resistance to O3-induced lung hyperpermeability in the HeJ strain [2].
  • METHODS: Dermal fibroblasts were obtained from 8- to 12-week-old iNOS--knock out (KO; C57BL/Ai-[KO] Nos2 N5) and wild type mice by an explant technique and used after 1 to 3 passages [3].

References

  1. Functional redundancy among Nanos proteins and a distinct role of Nanos2 during male germ cell development. Suzuki, A., Tsuda, M., Saga, Y. Development (2007) [Pubmed]
  2. Toll-like receptor 4 mediates ozone-induced murine lung hyperpermeability via inducible nitric oxide synthase. Kleeberger, S.R., Reddy, S.P., Zhang, L.Y., Cho, H.Y., Jedlicka, A.E. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  3. The role of iNOS in wound healing. Shi, H.P., Most, D., Efron, D.T., Tantry, U., Fischel, M.H., Barbul, A. Surgery (2001) [Pubmed]
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