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Gene Review

MALAT1  -  metastasis associated lung adenocarcinoma...

Homo sapiens

Synonyms: HCN, LINC00047, MALAT-1, Metastasis-associated lung adenocarcinoma transcript 1, NCRNA00047, ...
 
 
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Disease relevance of MALAT1

  • Several of the identified genes (eIF4A1, thymosin beta4 and a novel transcript named MALAT-1) were demonstrated to be significantly associated with metastasis in NSCLC patients (n=70) [1].
  • MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer [1].
  • After suppression subtractive hybridization and differential screening, we detected the metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) gene as one of the major genes upregulated in ESS, and a full-length placental cDNA clone (CS0DI066YJ10) as one of the major genes downregulated [2].
  • The resulting sequences were affiliated with the Alpha proteobacteria (n=19), the Actinobacteria (n=15), the Beta proteobacteria (n=2), and the Chloroflexi (n=2) lineages [3].
  • The results indicate that most of the clones found in the polluted culture correspond to well-known oil-degrading and nitrogen-fixing microorganisms, and belong to different phylogenetic groups, such as the Alpha, Beta, and Gamma subclasses of Proteobacteria, and the Cytophaga/Flavobacteria/Bacteroides group [4].
 

Psychiatry related information on MALAT1

  • Factor and reliability analysis were utilized to develop aggregate measures for self-efficacy (Cronbach's Alpha 0.60), intimacy (Cronbach's Alpha 0.80), and environmental-structural support (Cronbach's Alpha 0.72) [5].
 

High impact information on MALAT1

  • Although the Alpha promoter drives expression of this fusion gene, the Alpha gene does not contribute to the ORF [6].
  • Here we show that in t(6;11)(p21;q13)-positive RCCs the TFEB gene on chromosome 6 is fused to the Alpha gene on chromosome 11 [7].
  • The novel MALAT-1 transcript is a noncoding RNA of more than 8000 nt expressed from chromosome 11q13 [1].
  • However, Stat-1alpha and pS2 protein expression was only increased in the tumorigenic Alpha 5 and Tumor 2 cell lines [8].
  • The MCF-10F cells that were irradiated with double doses of alpha-particles in the presence of estrogen (60 cGy + E/60 cGy + E, named Alpha 5) showed gradual phenotypic changes relative to control, including tumorigenicity in heterologous animals [8].
 

Biological context of MALAT1

  • The AlphaTFEB fusion gene appears to contain all coding exons of the TFEB gene linked to 5' upstream regulatory sequences of the Alpha gene [7].
  • RESULTS: U.S. Public Health Service criteria showed 100% Alpha scores concerning recurrent caries for both crowns and FPDs [9].
  • alpha-particle-induced nuclear reactions for generation of (211)At used in therapeutic nuclear medicine and possible contaminants were investigated with the stacked foil activation technique on natural bismuth targets up to E(alpha)=39 MeV [10].
  • The interaction between hGSTA1-1 (human class Alpha GST with two type 1 subunits) and a non-substrate anionic ligand, BSP (bromosulphophthalein), was studied by isothermal titration calorimetry and inhibition kinetics [11].
 

Anatomical context of MALAT1

  • All ESS (4/4) and all cases of endometrial stromal cells in the proliferative phase (13/13) were positive for MALAT-1, but samples of normal stroma in the secretory phase and menopausal state included some that were negative or weakly positive for MALAT-1 (5/13 and 3/10, respectively) [2].
  • alpha-blocker monotherapy in the treatment of nocturia in men with lower urinary tract symptoms: a prospective study of response prediction [12].
 

Associations of MALAT1 with chemical compounds

  • METHODS: Equibiaxial disks were fabricated with RLH of 1:2, 1:1 and 2:1, for In-Ceram Alumina and Vitadur Alpha porcelain, respectively [13].
  • METHODS: Six porcelains were tested: A (Ceramco I/Dentsply), B (Ceramco II/Dentsitply), C (Finesse/Dentsply), D (d.Sign/Ivoclar), Cb (Cerabien/Noritake) and V (Vitadur Alpha/Vita) [14].
  • Chemistry of rocks and soils at Meridiani Planum from the Alpha Particle X-ray Spectrometer [15].
  • This paper describes a practical calibration system and the actual calibration verification data obtained at different flow rates, for E-PERM passive radon monitors, Femto-Tech and Alpha Guard Continuous Radon Monitors [16].
 

Other interactions of MALAT1

  • The marginal adaptation was rated as partly sealed (Oscar-Alpha) in 107 (92.2) of the restorations [17].
 

Analytical, diagnostic and therapeutic context of MALAT1

  • Sequence analysis of this fragment revealed its homology with the human Topoisomerase II Alpha gene [18].
  • Monte Carlo dosimetric study of best industries and Alpha Omega Ir-192 brachytherapy seeds [19].
  • Gross mechanical efficiency and propulsion technique variables were measured with Oxycon Alpha and an instrumented wheelchair ergometer [20].
  • We started to use a low-prime ECMO with small centrifugal pump (HPM-15) and membrane oxygenator (MENOX Alpha Cube) for induction of ECMO beginning in 2000 [21].
  • The AlD3 obtained was a mixture of about 2/3alpha and 1/3alpha'. Alpha' was determined by powder neutron diffraction to take the beta-AlF3 structure with space group Cmcm and a = 6.470(3), b = 11.117(5), and c = 6.562(2) A [22].

References

  1. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Ji, P., Diederichs, S., Wang, W., Böing, S., Metzger, R., Schneider, P.M., Tidow, N., Brandt, B., Buerger, H., Bulk, E., Thomas, M., Berdel, W.E., Serve, H., Müller-Tidow, C. Oncogene (2003) [Pubmed]
  2. Phenotypic characterization of endometrial stromal sarcoma of the uterus. Yamada, K., Kano, J., Tsunoda, H., Yoshikawa, H., Okubo, C., Ishiyama, T., Noguchi, M. Cancer Sci. (2006) [Pubmed]
  3. Microbial diversity of the freshwater sponge Spongilla lacustris. Gernert, C., Glöckner, F.O., Krohne, G., Hentschel, U. Microb. Ecol. (2005) [Pubmed]
  4. Molecular characterization of an oil-degrading cyanobacterial consortium. Sánchez, O., Diestra, E., Esteve, I., Mas, J. Microb. Ecol. (2005) [Pubmed]
  5. Environmental-structural factors significantly associated with consistent condom use among female sex workers in the Dominican Republic. Kerrigan, D., Ellen, J.M., Moreno, L., Rosario, S., Katz, J., Celentano, D.D., Sweat, M. AIDS (2003) [Pubmed]
  6. Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. Davis, I.J., Hsi, B.L., Arroyo, J.D., Vargas, S.O., Yeh, Y.A., Motyckova, G., Valencia, P., Perez-Atayde, A.R., Argani, P., Ladanyi, M., Fletcher, J.A., Fisher, D.E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution. Kuiper, R.P., Schepens, M., Thijssen, J., van Asseldonk, M., van den Berg, E., Bridge, J., Schuuring, E., Schoenmakers, E.F., van Kessel, A.G. Hum. Mol. Genet. (2003) [Pubmed]
  8. Growth factor biomarkers associated with estrogen- and radiation-induced breast cancer progression. Calaf, G.M., Roy, D., Hei, T.K. Int. J. Oncol. (2006) [Pubmed]
  9. Two-year clinical evaluation of lithia-disilicate-based all-ceramic crowns and fixed partial dentures. Taskonak, B., Sertg??z, A. Dental materials : official publication of the Academy of Dental Materials. (2006) [Pubmed]
  10. Experimental study of the cross-sections of alpha-particle induced reactions on 209Bi. Hermanne, A., Tárkányi, F., Takács, S., Szücs, Z., Shubin, Y.N., Dityuk, A.I. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. (2005) [Pubmed]
  11. Characterization of bromosulphophthalein binding to human glutathione S-transferase A1-1: thermodynamics and inhibition kinetics. Kolobe, D., Sayed, Y., Dirr, H.W. Biochem. J. (2004) [Pubmed]
  12. alpha-blocker monotherapy in the treatment of nocturia in men with lower urinary tract symptoms: a prospective study of response prediction. Paick, J.S., Ku, J.H., Shin, J.W., Yang, J.H., Kim, S.W. BJU international. (2006) [Pubmed]
  13. Determining the slow crack growth parameter and Weibull two-parameter estimates of bilaminate disks by constant displacement-rate flexural testing. Thompson, G.A. Dental materials : official publication of the Academy of Dental Materials. (2004) [Pubmed]
  14. Correlation between fracture toughness and leucite content in dental porcelains. Cesar, P.F., Yoshimura, H.N., Miranda Júnior, W.G., Okada, C.Y. Journal of dentistry. (2005) [Pubmed]
  15. Chemistry of rocks and soils at Meridiani Planum from the Alpha Particle X-ray Spectrometer. Rieder, R., Gellert, R., Anderson, R.C., Brückner, J., Clark, B.C., Dreibus, G., Economou, T., Klingelhöfer, G., Lugmair, G.W., Ming, D.W., Squyres, S.W., d'Uston, C., Wänke, H., Yen, A., Zipfel, J. Science (2004) [Pubmed]
  16. Radon monitor calibration using NIST radon emanation standards: steady flow method. Kotrappa, P., Stieff, L.R., Volkovitsky, P. Radiation protection dosimetry. (2005) [Pubmed]
  17. Three-year clinical evaluation of a polyacid-modified resin composite in minimally invasive occlusal cavities. Cehreli, Z.C., Altay, N. Journal of dentistry. (2000) [Pubmed]
  18. Somatostatin up-regulates topoisomerase II alpha expression and affects LNCaP cell cycle. Brevini-Gandolfi, T.A., Cillo, F., Favetta, L.A., Montagna, A., Motta, M. Mol. Cell. Endocrinol. (2001) [Pubmed]
  19. Monte Carlo dosimetric study of best industries and Alpha Omega Ir-192 brachytherapy seeds. Ballester, F., Granero, D., Pérez-Calatayud, J., Casal, E., Puchades, V. Medical physics. (2004) [Pubmed]
  20. Effect of wheelchair stroke pattern on mechanical efficiency. de Groot, S., Veeger, H.E., Hollander, A.P., van der Woude, L.H. American journal of physical medicine & rehabilitation / Association of Academic Physiatrists. (2004) [Pubmed]
  21. Early experience with low-prime (99 ml) extracorporeal membrane oxygenation support in children. Yamasaki, Y., Hayashi, T., Nakatani, T., Yotsuida, H., Nishigaki, T., Takahashi, Y., Inamori, S., Kagisaki, K., Hagino, H., Ishizaka, T., Yagihara, T. ASAIO journal (American Society for Artificial Internal Organs : 1992) (2006) [Pubmed]
  22. Mechanochemical synthesis and crystal structure of alpha'-AlD3 and alpha-AlD3. Brinks, H.W., Istad-Lem, A., Hauback, B.C. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical (2006) [Pubmed]
 
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