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Gene Review:

TERC - telomerase RNA component

Gallus gallus

Trapp, S. et al., Swanberg, S.E. et al., Artandi, S.E., Delany, M.E. et al.

Artandi, Delany, Daniels,

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Disease relevance of LOC379037

New data now suggest that a viral telomerase RNA gene encoded by Marek's disease virus (MDV), an oncogenic herpesvirus of chickens, promotes tumor formation [1].
Marek's disease herpesvirus (MDV) induces a malignant T cell lymphoma in chickens and harbors in its genome two identical copies of a viral TR (vTR) with 88% sequence identity to chicken TR [2].

High impact information on LOC379037

A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis [2].
This study examined telomerase activity and gene expression profiles for three genes in Gallus gallus domesticus: telomerase reverse transcriptase (chTERT), telomerase RNA (chTR), and c-myc [3].
The chicken telomerase RNA gene: conservation of sequence, regulatory elements and synteny among viral, avian and mammalian genomes [4].

References

Telomerase flies the coop: the telomerase RNA component as a viral-encoded oncogene. Artandi, S.E. J. Exp. Med. (2006) [Pubmed]
A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis. Trapp, S., Parcells, M.S., Kamil, J.P., Schumacher, D., Tischer, B.K., Kumar, P.M., Nair, V.K., Osterrieder, N. J. Exp. Med. (2006) [Pubmed]
Telomerase activity and differential expression of telomerase genes and c-myc in chicken cells in vitro. Swanberg, S.E., Payne, W.S., Hunt, H.D., Dodgson, J.B., Delany, M.E. Dev. Dyn. (2004) [Pubmed]
The chicken telomerase RNA gene: conservation of sequence, regulatory elements and synteny among viral, avian and mammalian genomes. Delany, M.E., Daniels, L.M. Cytogenet. Genome Res. (2003) [Pubmed]

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