The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

Table of contents

About

Terms

 

Gene Review: 

aur  -  zinc metalloproteinase aureolysin

Staphylococcus aureus RF122

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of aur

 

High impact information on aur

  • Our data indicate that bacterial killing activity of human peripheral blood neutrophils against P. aerug. or S. aur. is not decreased in buffers in which NaCl was replaced with equimolar concentrations of choline Cl, KCl, or N-methyl-D-glucamine chloride to maintain isotonicity [2].
  • Using a mouse abscess model, it has been shown that insertional inactivation of sspA or sspB results in significant attenuation of virulence, whilst mutations in aur or scpA do not [3].
  • As the interactions between all regulators that control protease gene expression are not fully understood, the present study was undertaken to elucidate the regulatory network governing aureolysin (aur) and staphylococcal serine protease (sspA) transcription [1].
 

Analytical, diagnostic and therapeutic context of aur

  • The aur gene was detected in all 74 isolates from cows, pigs and chickens by PCR amplification and was classified into types I and II by PCR-RFLP patterns [4].

References

  1. Coordinated and differential control of aureolysin (aur) and serine protease (sspA) transcription in Staphylococcus aureus by sarA, rot and agr (RNAIII). Oscarsson, J., Tegmark-Wisell, K., Arvidson, S. Int. J. Med. Microbiol. (2006) [Pubmed]
  2. Effects of ion composition and tonicity on human neutrophil antibacterial activity. Verghese, M.W., Boucher, R.C. Am. J. Respir. Cell Mol. Biol. (1998) [Pubmed]
  3. The role and regulation of the extracellular proteases of Staphylococcus aureus. Shaw, L., Golonka, E., Potempa, J., Foster, S.J. Microbiology (Reading, Engl.) (2004) [Pubmed]
  4. Genetic and enzymatic analyses of metalloprotease (aureolysin) from Staphylococcus aureus isolated from domestic animals. Takeuchi, S., Saito, M., Imaizumi, K., Kaidoh, T., Higuchi, H., Inubushi, S. Vet. Microbiol. (2002) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities