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Gene Review:

dltA - D-alanine--poly(phosphoribitol) ligase...

Staphylococcus aureus RF122

Koprivnjak, T. et al., Koprivnjak, T. et al., Weidenmaier, C. et al.

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High impact information on dltA

To further delineate charge properties of the bacterial envelope important in Group IIA PLA(2) action against S. aureus, we examined the effects of mutations that prevent specific modifications of cell wall (dltA) and cell membrane (mprF) polyanions [1].
However, only the dltA mutation significantly reduced metastatic infections in kidneys and spleens compared to those in animals infected with the parental strain [2].
Northern blotting, reverse transcription-PCR, and SMART-RACE analyses suggest that the dlt transcript begins 250 bp upstream of the dltA start codon and includes an open reading frame immediately upstream of dltA [3].
Chloramphenicol transacetylase transcriptional fusions indicate that a region encompassing the 171 to 325 bp upstream of dltA is required for expression and Mg(2+)-induced repression of the dlt operon in S. aureus [3].

References

Role of charge properties of bacterial envelope in bactericidal action of human group IIA phospholipase A2 against Staphylococcus aureus. Koprivnjak, T., Peschel, A., Gelb, M.H., Liang, N.S., Weiss, J.P. J. Biol. Chem. (2002) [Pubmed]
DltABCD- and MprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis model. Weidenmaier, C., Peschel, A., Kempf, V.A., Lucindo, N., Yeaman, M.R., Bayer, A.S. Infect. Immun. (2005) [Pubmed]
Cation-Induced Transcriptional Regulation of the dlt Operon of Staphylococcus aureus. Koprivnjak, T., Mlakar, V., Swanson, L., Fournier, B., Peschel, A., Weiss, J.P. J. Bacteriol. (2006) [Pubmed]

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