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Gene Review

Rxfp1  -  relaxin/insulin-like family peptide...

Mus musculus

Synonyms: Gm1018, LOC381489, Leucine-rich repeat-containing G-protein coupled receptor 7, Lgr7, Relaxin family peptide receptor 1, ...
 
 
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Disease relevance of Rxfp1

  • Histological analysis of Lgr7 mutant lung tissues demonstrates increased collagen accumulation and fibrosis surrounding the bronchioles and the vascular bundles, absent in wild-type animals [1].
 

High impact information on Rxfp1

  • Lgr7-deficient females with additional deletion of Lgr8 (Great), another putative receptor for RLN, are fertile and have normal-sized litters [1].
  • However, Lgr7-deficient males do not exhibit abnormalities in the testes or prostate as seen in Rln1 knockout mice [1].
  • Transgenic overexpression of Insl3, the cognate ligand for Lgr8, does not rescue the mutant phenotype of Lgr7-deficient female mice indicating nonoverlapping functions of the two receptors [1].
  • Relaxin-1 and its major receptor, Lgr7, mRNA are expressed in thoracic aortas, small renal and mesenteric arteries from mice and rats of both sexes, as well as in small renal arteries from female tammar wallabies (an Australian marsupial) [2].

References

  1. Genetic targeting of relaxin and insulin-like factor 3 receptors in mice. Kamat, A.A., Feng, S., Bogatcheva, N.V., Truong, A., Bishop, C.E., Agoulnik, A.I. Endocrinology (2004) [Pubmed]
  2. Evidence for local relaxin ligand-receptor expression and function in arteries. Novak, J., Parry, L.J., Matthews, J.E., Kerchner, L.J., Indovina, K., Hanley-Yanez, K., Doty, K.D., Debrah, D.O., Shroff, S.G., Conrad, K.P. FASEB J. (2006) [Pubmed]
 
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