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Taok2  -  TAO kinase 2

Mus musculus

Synonyms: 1110033K02Rik, B230344N16, Kiaa0881, MAP3K17, PSK, ...
 
 
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Disease relevance of Taok2

  • We found that mutant Ras blocks serum- and 12-O-tetradecanoyl phorbol 13-acetate-induced activation of Raf-1 kinase in NIH3T3 cells and Raf-1 as well as B-Raf PSK stimulation by nerve growth factor (NGF) in PC12 pheochromocytoma cells [1].
  • Treatment of RadLV-inoculated mice with PSK delayed the onset of overt lymphoma (and mortality) but could not protect the mice from the disease [2].
  • The results suggest that PSK could be used as a prophylactic immune response modifier in preleukemia [3].
 

High impact information on Taok2

  • Additionally, the intracellular PSK oncogene, mos and the nuclear oncogenes c-myc, c-fos, and SV40 T antigen were TAM 67-sensitive for transformation [4].
  • Effect of PSK on the maturation of dendritic cells derived from human peripheral blood monocytes [5].
  • Furthermore, we observed the down-regulation of the mRNA expression and protein level of transforming growth factor beta (TGFbeta) in the tumor tissues treated with PSK, and that in vitro treatment of QR-32 cells with TGFbeta decreased the production of Mn-SOD [6].
  • The response was transient and was accompanied with a dominant usage of T cells expressing V beta 8, but other T cell subsets were also stimulated by PSK [2].
  • T lymphoma cells expressing V beta 8.2 underwent apoptosis when incubated with PSK [2].
 

Anatomical context of Taok2

  • The results suggest that PSK contains a superantigen-like component that selectively activates V beta 8+ T cells [2].
  • We examined the effect of PSK on the maturation of DC derived from CD14-positive cells obtained from human peripheral blood monocytes using a negative selection method [5].
  • The dual immunostimulating activity of PSK resulted in the generation of T cytotoxic lymphocytes that could lyse lymphoma cells in vitro [3].
 

Analytical, diagnostic and therapeutic context of Taok2

  • The clinical significance of the combined use of PSK in DC vaccine therapy remains for study [5].
  • Polysaccharide K (PSK) is a biological response modifier used for adjuvant immunotherapy of malignant diseases [2].

References

  1. Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol. Troppmair, J., Bruder, J.T., App, H., Cai, H., Liptak, L., Szeberényi, J., Cooper, G.M., Rapp, U.R. Oncogene (1992) [Pubmed]
  2. Prophylactic intervention in radiation-leukemia-virus-induced murine lymphoma by the biological response modifier polysaccharide K. Yefenof, E., Gafanovitch, I., Oron, E., Bar, M., Klein, E. Cancer Immunol. Immunother. (1995) [Pubmed]
  3. Potentiation of T cell immunity against radiation-leukemia-virus-induced lymphoma by polysaccharide K. Yefenof, E., Einat, E., Klein, E. Cancer Immunol. Immunother. (1991) [Pubmed]
  4. Transformation by Raf and other oncogenes renders cells differentially sensitive to growth inhibition by a dominant negative c-jun mutant. Rapp, U.R., Troppmair, J., Beck, T., Birrer, M.J. Oncogene (1994) [Pubmed]
  5. Effect of PSK on the maturation of dendritic cells derived from human peripheral blood monocytes. Kanazawa, M., Mori, Y., Yoshihara, K., Iwadate, M., Suzuki, S., Endoh, Y., Ohki, S., Takita, K., Sekikawa, K., Takenoshita, S. Immunol. Lett. (2004) [Pubmed]
  6. Polysaccharide K induces Mn superoxide dismutase (Mn-SOD) in tumor tissues and inhibits malignant progression of QR-32 tumor cells: possible roles of interferon alpha, tumor necrosis factor alpha and transforming growth factor beta in Mn-SOD induction by polysaccharide K. Habelhah, H., Okada, F., Nakai, K., Choi, S.K., Hamada, J., Kobayashi, M., Hosokawa, M. Cancer Immunol. Immunother. (1998) [Pubmed]
 
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