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Gene Review:

Ripply2 - ripply2 homolog (zebrafish)

Mus musculus

Synonyms: C030002E08Rik, Gm1122, LOC382089, Protein ripply2

Morimoto, M. et al.

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High impact information on C030002E08Rik

We then examined whether Ripply2 is responsible for the repression of genes under the control of Mesp2 by generating a Ripply2-knockout mouse [1].
Our study demonstrates that a Ripply2-Mesp2 negative-feedback loop is essential for the periodic generation of the rostro-caudal polarity within a somite [1].

Biological context of C030002E08Rik

Unexpectedly, Ripply2-null embryos show a rostralized phenotype, in contrast to Mesp2-null mice [1].

Anatomical context of C030002E08Rik

The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite [1].

References

The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite. Morimoto, M., Sasaki, N., Oginuma, M., Kiso, M., Igarashi, K., Aizaki, K., Kanno, J., Saga, Y. Development (2007) [Pubmed]

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RIPPLY2	Bos taurus
RIPPLY2	Homo sapiens
RIPPLY2	Macaca mulatta
RIPPLY2	Pan troglodytes
Ripply2	Rattus norvegicus

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