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Gene Review

YBX1  -  Y box binding protein 1

Gallus gallus

Synonyms: NSEP1, YB1
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High impact information on YBX1

  • Through the immunoprecipitation of an epitope-tagged YB-1 protein, which complemented the slow-growth phenotype of YB-1-depleted cells, we isolated YB-1-associated complexes that likely represented general mRNPs in somatic cells [1].
  • We present several lines of evidence that YB-1 expression in the liver is positively associated with DNA synthesis or cell proliferation [2].
  • The increased levels of expression of YB-1 during proliferation combined with its binding characteristics suggest that it may be involved in the reduced expression of liver-specific genes observed at early stages of development or during liver regeneration [2].
  • We have recently reported that fibroblast nuclear proteins, including chicken Y-box-binding protein 1, bind to this single-stranded pyrimidine-rich sequence [3].


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