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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MED4  -  Mediator complex subunit 4

Drosophila melanogaster

Synonyms: CG8609, Dmel\CG8609, Med4, Med4/TRAP36, Mediator of RNA polymerase II transcription subunit 4, ...
 
 
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High impact information on MED4

  • Here, we show that upon heat shock the Pol II-free form of Mediator is rapidly recruited to HSF binding sites [1].
  • Recruitment of the Mediator complex by transcriptional activators is usually the key step in transcriptional activation [2].
  • MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators [2].
  • Here we identify one of these proteins, encoded by the previously uncharacterized AK000411 open reading frame, as a new subunit of the mammalian Mediator complex [3].
  • The TRAP/SMCC/Mediator complex and thyroid hormone receptor function [4].

References

  1. Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock. Park, J.M., Werner, J., Kim, J.M., Lis, J.T., Kim, Y.J. Mol. Cell (2001) [Pubmed]
  2. MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators. Kim, T.W., Kwon, Y.J., Kim, J.M., Song, Y.H., Kim, S.N., Kim, Y.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. Sato, S., Tomomori-Sato, C., Banks, C.A., Parmely, T.J., Sorokina, I., Brower, C.S., Conaway, R.C., Conaway, J.W. J. Biol. Chem. (2003) [Pubmed]
  4. The TRAP/SMCC/Mediator complex and thyroid hormone receptor function. Ito, M., Roeder, R.G. Trends Endocrinol. Metab. (2001) [Pubmed]
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