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Gene Review

LAIR1  -  leukocyte-associated immunoglobulin-like...

Homo sapiens

Synonyms: CD305, LAIR-1, Leukocyte-associated immunoglobulin-like receptor 1, hLAIR1
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Disease relevance of LAIR1


High impact information on LAIR1


Biological context of LAIR1

  • Protein kinases responsible for tyrosine phosphorylation of LAIR-1 may belong to the Src family since PP1, a Src family kinase inhibitor, significantly inhibited its phosphorylation [6].
  • Ligand engagement of the SH2 domains of SHP-1 is a prerequisite to activation of the enzyme, and, consistent with an association with LAIR-1, SHP-1 was found to be constitutively active in unstimulated Jurkat T cells [7].
  • Indeed, leukemia cells stimulated with GM-CSF were blocked in the G0/G1 phase of the cell cycle and underwent apoptosis within 4 days after the engagement of LAIR-1 [8].
  • SHP-1 mutation in mice results in abnormal lymphoproliferation, suggesting that LAIR-1 may also be implicated in regulating hematopoiesis [9].
  • This was evident already 8 h after LAIR-1 occupancy, when apoptosis was not yet detectable by fluorometric or ultrastructural analysis [10].

Anatomical context of LAIR1


Associations of LAIR1 with chemical compounds


Physical interactions of LAIR1


Enzymatic interactions of LAIR1

  • LAIR-1 is hyper-phosphorylated on tyrosyl residues in cells overexpressing a catalytically inactive mutant form of SHP-1 as well as in pervanadate-treated cells [6].

Regulatory relationships of LAIR1

  • Altogether, these findings indicate that the engagement of LAIR-1 can down-regulate GM-CSF-mediated survival and proliferation of AML blasts, suggesting an additional therapeutic approach to the treatment of AML patients [8].
  • This finding provided the first evidence that LAIR-1 expresses on hematopoietic progenitor, implicating its role in the regulation of hematopoiesis at early stage [9].

Other interactions of LAIR1


Analytical, diagnostic and therapeutic context of LAIR1


  1. Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells. Aoukaty, A., Lee, I.F., Wu, J., Tan, R. J. Clin. Immunol. (2003) [Pubmed]
  2. Establishment of an ELISA system for determining soluble LAIR-1 levels in sera of patients with HFRS and kidney transplant. Ouyang, W., Xue, J., Liu, J., Jia, W., Li, Z., Xie, X., Liu, X., Jian, J., Li, Q., Zhu, Y., Yang, A., Jin, B. J. Immunol. Methods (2004) [Pubmed]
  3. Identification and characterization of the rat homologue of LAIR-1. Lebbink, R.J., de Ruiter, T., Kaptijn, G.J., Meyaard, L. Immunogenetics (2005) [Pubmed]
  4. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. Meyaard, L., Adema, G.J., Chang, C., Woollatt, E., Sutherland, G.R., Lanier, L.L., Phillips, J.H. Immunity (1997) [Pubmed]
  5. The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR). Meyaard, L., van der Vuurst de Vries, A.R., de Ruiter, T., Lanier, L.L., Phillips, J.H., Clevers, H. J. Exp. Med. (2001) [Pubmed]
  6. Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells. Xu, M., Zhao, R., Zhao, Z.J. J. Biol. Chem. (2000) [Pubmed]
  7. Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells. Sathish, J.G., Johnson, K.G., Fuller, K.J., LeRoy, F.G., Meyaard, L., Sims, M.J., Matthews, R.J. J. Immunol. (2001) [Pubmed]
  8. Leukocyte-associated Ig-like receptor-1 prevents granulocyte-monocyte colony stimulating factor-dependent proliferation and Akt1/PKB alpha activation in primary acute myeloid leukemia cells. Zocchi, M.R., Pellegatta, F., Pierri, I., Gobbi, M., Poggi, A. Eur. J. Immunol. (2001) [Pubmed]
  9. 9.1C3 is identical to LAIR-1, which is expressed on hematopoietic progenitors. Ouyang, W., Ma, D., Lin, D., Sun, Y., Liu, X., Li, Q., Jia, W., Cao, Y., Zhu, Y., Jin, B. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  10. Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias. Poggi, A., Pellegatta, F., Leone, B.E., Moretta, L., Zocchi, M.R. Eur. J. Immunol. (2000) [Pubmed]
  11. Differential gene expression by integrin beta 7+ and beta 7- memory T helper cells. Rodriguez, M.W., Paquet, A.C., Yang, Y.H., Erle, D.J. BMC Immunol. (2004) [Pubmed]
  12. Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells. Meyaard, L., Hurenkamp, J., Clevers, H., Lanier, L.L., Phillips, J.H. J. Immunol. (1999) [Pubmed]
  13. Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling. van der Vuurst de Vries, A.R., Clevers, H., Logtenberg, T., Meyaard, L. Eur. J. Immunol. (1999) [Pubmed]
  14. Differential expression of leukocyte-associated Ig-like receptor-1 during neutrophil differentiation and activation. Verbrugge, A., de Ruiter, T., Geest, C., Coffer, P.J., Meyaard, L. J. Leukoc. Biol. (2006) [Pubmed]
  15. The mouse homologue of the leukocyte-associated Ig-like receptor-1 is an inhibitory receptor that recruits Src homology region 2-containing protein tyrosine phosphatase (SHP)-2, but not SHP-1. Lebbink, R.J., de Ruiter, T., Verbrugge, A., Bril, W.S., Meyaard, L. J. Immunol. (2004) [Pubmed]
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