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Gene Review

CalpB  -  Calpain-B

Drosophila melanogaster

Synonyms: CALPB, CANP B, CG8107, Calcium-activated neutral proteinase B, Dmel\CG8107, ...
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Disease relevance of CalpB

  • The amino acid preferences were confirmed by site-directed mutagenesis of the autolysis sites of Drosophila calpain B; when amino acids at key positions were changed to less preferred ones, autolytic cleavage shifted to other, adjacent sites [1].

High impact information on CalpB


Biological context of CalpB

  • The enzymes undergo N-terminal autolysis in a Ca(2+)-dependent manner which was shown with CALPB to run parallel with enzyme activation [3].
  • In similar assays, DUK114 was ineffective with Drosophila calpain A or calpain B. To test for its chaperone activity in vivo, DUK114 was transfected into Schneider (S2) cells; after heat shock, the number of viable non-transfected cells started to increase after a lag time; in the presence of DUK114, cell proliferation started at once [5].

Other interactions of CalpB


  1. On the sequential determinants of calpain cleavage. Tompa, P., Buzder-Lantos, P., Tantos, A., Farkas, A., Szilágyi, A., Bánóczi, Z., Hudecz, F., Friedrich, P. J. Biol. Chem. (2004) [Pubmed]
  2. The calpain-system of Drosophila melanogaster: coming of age. Friedrich, P., Tompa, P., Farkas, A. Bioessays (2004) [Pubmed]
  3. Characterization of two recombinant Drosophila calpains. CALPA and a novel homolog, CALPB. Jékely, G., Friedrich, P. J. Biol. Chem. (1999) [Pubmed]
  4. Autolytic activation and localization in Schneider cells (S2) of calpain B from Drosophila. Farkas, A., Tompa, P., Schád, E., Sinka, R., Jékely, G., Friedrich, P. Biochem. J. (2004) [Pubmed]
  5. DUK114, the Drosophila orthologue of bovine brain calpain activator protein, is a molecular chaperone. Farkas, A., Nardai, G., Csermely, P., Tompa, P., Friedrich, P. Biochem. J. (2004) [Pubmed]
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