Gene Review:
chrb - charybde
Drosophila melanogaster
Synonyms:
BcDNA:GH09771, CG7533, Dmel\CG7533, EP(3)1035, Protein charybde, ...
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High impact information on chrb
- The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila [1].
- Together, genetic and biochemical analysis places Scylla/Charybdis downstream of PKB and upstream of TSC [1].
- Furthermore, we show that scylla and charybdis are induced under hypoxic conditions and that scylla is a target of Drosophila HIF-1 (hypoxia-inducible factor-1) like its mammalian counterpart RTP801/REDD1, thus establishing a potential cross-talk between growth and oxygen sensing [1].
Biological context of chrb
- Here we show that scylla and charybdis, two homologous genes identified as growth suppressors in an EP (enhancer/promoter) overexpression screen, act as negative regulators of growth [1].
Other interactions of chrb
References
- The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Reiling, J.H., Hafen, E. Genes Dev. (2004) [Pubmed]
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