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LECT2  -  leukocyte cell-derived chemotaxin 2

Homo sapiens

Synonyms: LECT-2, Leukocyte cell-derived chemotaxin-2, chm-II, chm2, hLECT2
 
 
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Disease relevance of LECT2

 

High impact information on LECT2

  • LECT2 expression was not activated in livers in which hepatocyte proliferation was induced by a beta-catenin-independent signal [1].
  • We further characterized the chemotactic property of LECT2 for human neutrophils [1].
  • We characterized by mutagenesis the LEF/TCF site, which is crucial for LECT2 activation by beta-catenin [1].
  • Val58Ile polymorphism of the neutrophil chemoattractant LECT2 and rheumatoid arthritis in the Japanese population [4].
  • Two types of mouse Lect2 cDNAs were cloned: one encoded the mouse counterpart of human and bovine LECT2 proteins, and the other encoded a queer type LECT2 protein whose amino-acid sequence in the carboxy terminus was different from that of the normal type LECT2 protein [5].
 

Chemical compound and disease context of LECT2

 

Biological context of LECT2

 

Anatomical context of LECT2

  • The monomer composition was significantly improved to 81% by the three-step refolding method and the monomer thus obtained was shown to have the same conformation as the authentic LECT2 produced in CHO cells by CD and NMR spectroscopies [9].
  • In the present study, we investigated the relationship between serum leukocyte cell-derived chemotaxin2 (LECT2) levels and liver function in patients with acute liver failure, and its use as a prognostic indicator [3].
 

Associations of LECT2 with chemical compounds

  • The data clearly demonstrate that LECT2 becomes essentially negative in full-blown HCC cells and that the histological distinction between AH and LGM-HCC is valid [6].
 

Other interactions of LECT2

 

Analytical, diagnostic and therapeutic context of LECT2

References

  1. Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of beta-catenin in the liver. Ovejero, C., Cavard, C., Périanin, A., Hakvoort, T., Vermeulen, J., Godard, C., Fabre, M., Chafey, P., Suzuki, K., Romagnolo, B., Yamagoe, S., Perret, C. Hepatology (2004) [Pubmed]
  2. Molecular cloning of leukocyte cell-derived chemotaxin 2 in rainbow trout. Kokkinos, P.A., Kazantzi, A., Sfyroera, G., Zarkadis, I.K. Fish Shellfish Immunol. (2005) [Pubmed]
  3. Serum LECT2 level as a prognostic indicator in acute liver failure. Sato, Y., Watanabe, H., Kameyama, H., Kobayashi, T., Yamamoto, S., Takeishi, T., Hirano, K., Oya, H., Nakatsuka, H., Watanabe, T., Kokai, H., Yamagoe, S., Suzuki, K., Oya, K., Kojima, K., Hatakeyama, K. Transplant. Proc. (2004) [Pubmed]
  4. Val58Ile polymorphism of the neutrophil chemoattractant LECT2 and rheumatoid arthritis in the Japanese population. Kameoka, Y., Yamagoe, S., Hatano, Y., Kasama, T., Suzuki, K. Arthritis Rheum. (2000) [Pubmed]
  5. The mouse Lect2 gene: cloning of cDNA and genomic DNA, structural characterization and chromosomal localization. Yamagoe, S., Watanabe, T., Mizuno, S., Suzuki, K. Gene (1998) [Pubmed]
  6. Expression pattern of a newly recognized protein, LECT2, in hepatocellular carcinoma and its premalignant lesion. Uchida, T., Nagai, H., Gotoh, K., Kanagawa, H., Kouyama, H., Kawanishi, T., Mima, S., Yamagoe, S., Suzuki, K. Pathol. Int. (1999) [Pubmed]
  7. Changes in serum LECT 2 levels during the early period of liver regeneration after adult living related donor liver transplantation. Sato, Y., Watanabe, H., Kameyama, H., Kobayashi, T., Yamamoto, S., Takeishi, T., Hirano, K., Oya, H., Nakatsuka, H., Watanabe, T., Kokai, H., Yamagoe, S., Suzuki, K., Oya, K., Kojima, K., Hatakeyama, K. Transplant. Proc. (2004) [Pubmed]
  8. Systemic expression of a newly recognized protein, LECT2, in the human body. Nagai, H., Hamada, T., Uchida, T., Yamagoe, S., Suzuki, K. Pathol. Int. (1998) [Pubmed]
  9. Expression, oxidative refolding, and characterization of six-histidine-tagged recombinant human LECT2, a 16-kDa chemotactic protein with three disulfide bonds. Ito, M., Nagata, K., Kato, Y., Oda, Y., Yamagoe, S., Suzuki, K., Tanokura, M. Protein Expr. Purif. (2003) [Pubmed]
  10. On the monophyletic evolution of the metazoa. Müller, W.E., Müller, I.M., Gamulin, V. Braz. J. Med. Biol. Res. (1994) [Pubmed]
 
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