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Gene Review

NEBL  -  nebulette

Gallus gallus

 
 
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High impact information on NEBL

  • To evaluate the role of nebulette in myofibrillogenesis, we have analyzed the expression of nebulette in chicken heart rudiments by immunoblots and immunofluorescence [1].
  • To distinguish this petite nebulin-like protein from the 600-900 kD skeletal muscle nebulin, we have named it nebulette [2].
  • To evaluate if nebulette, like nebulin, exhibits tissue-specific and developmental specific polymorphism, a series of immunoblot assays were performed [3].
  • Comparison of nebulette from embryonic and adult cardiac muscle also demonstrates that this protein does not appear to vary in size with developmental stage [3].
  • Although these proteins share 70% sequence homology and an identical domain layout, nebulette is one-tenth the size of nebulin [3].
 

Biological context of NEBL

References

  1. Expression of nebulette during early cardiac development. Esham, M., Bryan, K., Milnes, J., Holmes, W.B., Moncman, C.L. Cell Motil. Cytoskeleton (2007) [Pubmed]
  2. Nebulette: a 107 kD nebulin-like protein in cardiac muscle. Moncman, C.L., Wang, K. Cell Motil. Cytoskeleton (1995) [Pubmed]
  3. Architecture of the thin filament-Z-line junction: lessons from nebulette and nebulin homologies. Moncman, C.L., Wang, K. J. Muscle Res. Cell. Motil. (2000) [Pubmed]
 
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