Gene Review:
IRF10 - interferon regulatory factor 10
Gallus gallus
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High impact information on IRF10
- The cloning and functional characterization of a novel interferon regulatory factor (IRF), IRF-10, are described [1].
- IRF-10 is most closely related to IRF-4 but differs in both its constitutive and inducible expression [1].
- These results suggest that IRF-10 plays a role in the late stages of an immune defense by regulating the expression some of the IFN-gamma target genes in the absence of a cytotoxic effect [1].
- Moreover, v-Rel and IRF-4 synergistically cooperate in the induction of IRF-10 in fibroblasts [1].
- IRF-10 binds the interferon-stimulated response element site of the MHC class I promoter [1].
Biological context of IRF10
- In contrast to that of other IRFs, the inducible expression of IRF-10 is characterized by delayed kinetics and requires protein synthesis, suggesting a unique role in the later stages of an antiviral defense [1].
- The expression of IRF-10 is induced by the oncogene v-rel, the proto-oncogene c-rel, and IRF-4 in a tissue-specific manner [1].
- Accordingly, IRF-10 is involved in the upregulation of two primary IFN-gamma target genes (major histocompatibility complex [MHC] class I and guanylate-binding protein) and interferes with the induction of the type I IFN target gene for 2',5'-oligo(A) synthetase [1].
Anatomical context of IRF10
- The level of IRF-10 induction in lymphoid cell lines by Rel proteins correlates with Rel transformation potential [1].
- In contrast to that of IRF-1, which has some of the same functional characteristics, the expression of IRF-10 is not cytotoxic for fibroblasts or B cells [1].
References
- A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein. Nehyba, J., Hrdlicková, R., Burnside, J., Bose, H.R. Mol. Cell. Biol. (2002) [Pubmed]
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