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Gene Review:

CLTC - clathrin, heavy chain (Hc)

Gallus gallus

Solomonia, R.O. et al., McCabe, B.J. et al., Martin-Perez, J. et al.

McCabe, Nicol,

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Psychiatry related information on CLTC

These findings imply that for the left IMHV, visual experience per se, locomotor activity and other side effects of training did not affect the amount of clathrin heavy chain [1].

High impact information on CLTC

The phosphorylation of clathrin heavy chain in transformed cells may be linked to previously observed transformation-dependent alterations in receptor-mediated endocytosis of ligands such as EGF and thrombin [2].
Clathrin heavy chain and clathrin light chains a and b were assayed using sodium dodecyl sulphate polyacrylamide gel electrophoresis and immunoblotting [1].
The results for clathrin heavy chain taken together suggest that enhanced presynaptic events in the IMHV, possibly associated with an increase in synaptic vesicle release/uptake, are important in the recognition memory underlying imprinting [1].
There follow changes in phosphorylation of the protein kinase C substrate MARCKS, morphological changes in axospinous synapses, an increase in NMDA receptor number and increases in amounts of the major isoforms of the neural cell adhesion molecule and clathrin heavy chain [3].

References

Clathrin proteins and recognition memory. Solomonia, R.O., McCabe, B.J., Jackson, A.P., Horn, G. Neuroscience (1997) [Pubmed]
Transformation by Rous sarcoma virus induces clathrin heavy chain phosphorylation. Martin-Perez, J., Bar-Zvi, D., Branton, D., Erikson, R.L. J. Cell Biol. (1989) [Pubmed]
The recognition memory of imprinting: biochemistry and electrophysiology. McCabe, B.J., Nicol, A.U. Behav. Brain Res. (1999) [Pubmed]

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AgaP_AGAP003021	Anopheles gambiae str. PEST
AT3G11130	Arabidopsis thaliana
AT3G08530	Arabidopsis thaliana
AGOS_AER359W	Ashbya gossypii ATCC 10895
CLTC	Bos taurus
chc-1	Caenorhabditis elegans
CLTC	Canis lupus familiaris
cltca	Danio rerio
cltcb	Danio rerio
Chc	Drosophila melanogaster
CLTC	Homo sapiens
KLLA0F09911g	Kluyveromyces lactis NRRL Y-1140
CLTC	Macaca mulatta
MGG_07768	Magnaporthe oryzae 70-15
Cltc	Mus musculus
NCU02510	Neurospora crassa OR74A
CLTC	Pan troglodytes
Cltc	Rattus norvegicus
CHC1	Saccharomyces cerevisiae S288c
chc1	Schizosaccharomyces pombe 972h-
cltc	Xenopus (Silurana) tropicalis

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