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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SP3  -  Sp3 transcription factor

Gallus gallus

 
 
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High impact information on SP3

  • SP3/SP1 transcription activity regulates specific expression of collagen type X in hypertrophic chondrocytes [1].
  • This effect is negated by an interaction with SP3 in hypertrophic chondrocytes [1].
 

Other interactions of SP3

  • In the present study, we examined the role of SP3/SP1 transcription factors in the regulation of the Col10a1 promoter [1].
 

Analytical, diagnostic and therapeutic context of SP3

  • The SP3/SP1 ratio is higher in hypertrophic versus non-hypertrophic chondrocytes, due to the significant decrease in SP1 in hypertrophic cells detected by real-time PCR and Western blot analyses [1].
  • One dozen eggs were collected and analyzed from each of five different brands from hens fed a diet free of animal fat (SP1), certified organic free-range brown eggs (SP2), uncaged unmedicated brown eggs (SP3), cage-free vegetarian diet brown eggs (SP4), or naturally nested uncaged (SP5) [2].

References

  1. SP3/SP1 transcription activity regulates specific expression of collagen type X in hypertrophic chondrocytes. Magee, C., Nurminskaya, M., Faverman, L., Galera, P., Linsenmayer, T.F. J. Biol. Chem. (2005) [Pubmed]
  2. Fatty acid composition and egg components of specialty eggs. Cherian, G., Holsonbake, T.B., Goeger, M.P. Poult. Sci. (2002) [Pubmed]
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