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Gene Review

CD40  -  CD40 molecule, TNF receptor superfamily...

Gallus gallus

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High impact information on CD40

  • After lipopolysaccharide (LPS) stimulation, F4/80(+) SPMs expressed significantly higher levels of CD86, CD40, or MHC-II than F4/80(+) PEMs, but not CD11c, CD80, CD54, or CD23 [1].
  • These foci contained few B cells at the margins, but large numbers of CD4(+) and CD8(+) cells, scattered gammadelta(+) T-cells and macrophages, and small central aggregates of dendriticlike cells expressing the CD40 antigen [2].
  • These data suggest a possible role for CD40-CD40L interactions during EMT and the remodeling of the aorta [3].
  • CD40-CD40L expression was found on endothelial cells (ECs), mesenchymal cells, and smooth muscle cells (SMCs) at all stages examined, and appeared to be distributed across the aortic wall [3].

Biological context of CD40

  • Given the important role played by the CD40-CD40 ligand (CD40L) system during the initiation and progress of atherosclerosis, we investigated whether both CD40 and CD40L were present in the aortic wall during EMT and the advanced stages of chicken embryo development [3].


  1. The macrophage heterogeneity: Difference between mouse peritoneal exudate and splenic F4/80(+) macrophages. Liu, G., Xia, X.P., Gong, S.L., Zhao, Y. J. Cell. Physiol. (2006) [Pubmed]
  2. Infectious bursal disease virus-induced immunosuppression in the chick is associated with the presence of undifferentiated follicles in the recovering bursa. Withers, D.R., Young, J.R., Davison, T.F. Viral Immunol. (2005) [Pubmed]
  3. CD40 and CD40L expression in the chicken embryo aorta: possible role in the endothelial-mesenchymal transdifferentiation process. Arciniegas, E., Becerra, A., De Sanctis, J.B., Graterol, A., Ramírez, R. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2003) [Pubmed]
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