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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

POU4F3  -  POU class 4 homeobox 3

Gallus gallus

Synonyms: BRN-3, BRN3
 
 
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High impact information on POU4F3

  • We now describe the nucleotide sequence and proposed amino acid sequence of a chicken homologue to the murine and human Brn-3 genes [1].
  • Furthermore we characterise the early embryonic expression pattern of this chicken Brn-3 gene and show it to be expressed in peripheral sensory ganglia as well as in retinal ganglion cells [1].
  • The Brn-3 subfamily of POU-transcription factors constitutes a highly conserved group of such factors showing expression predominantly in sensory neurons [1].
  • We found that primary cultures of chicken embryonic RGCs express such RP markers as transcription factors Pax6 and Brn3, photopigment melanopsin, and G-protein q but not markers for ciliary photoreceptors (alpha-transducin and Crx) [2].

References

  1. Identification of a chicken homologue in the Brn-3 subfamily of POU-transcription factors. Lindeberg, J., Klint, P., Williams, R., Ebendal, T. Brain Res. Dev. Brain Res. (1997) [Pubmed]
  2. An invertebrate-like phototransduction cascade mediates light detection in the chicken retinal ganglion cells. Contin, M.A., Verra, D.M., Guido, M.E. FASEB J. (2006) [Pubmed]
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