The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GDNF  -  glial cell derived neurotrophic factor

Gallus gallus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of GDNF


High impact information on GDNF


Biological context of GDNF


Anatomical context of GDNF


Associations of GDNF with chemical compounds

  • Retinoic acid negatively regulates GDNF and neurturin receptor expression and responsiveness in embryonic chicken sympathetic neurons [10].
  • Like the members of the neurotrophin family, the GDNF-like growth factors belong structurally to the cysteine knot proteins [2].
  • This analysis was undertaken because GDNF is a potent survival factor for developing motoneurons and has been shown to protect this population from ethanol neurotoxicity [11].
  • Finally, the actions of GDNF are inhibited by PP2, an inhibitor of Src family tyrosine kinases, and by LY29003, an inhibitor of phosphatidylinositol 3 kinases, but not by PD98059, an inhibitor of the Erk signaling cascade [12].
  • The effects of GDNF on K(Ca) channel expression in LMNs require 24 hr of continuous exposure to reach maximum and are blocked by the translation inhibitor anisomycin, indicating the need for synthesis of new proteins [12].

Other interactions of GDNF

  • Unlike BDNF, neither GDNF, NT-4, nor IGF-I increased the survival of ION neurons in dissociated cultures identified by retrograde labeling with the fluorescent tracer DiI [7].
  • Overlapping and specific patterns of GDNF, c-ret and GFR alpha mRNA expression in the developing chicken retina [13].
  • Although GDNF displayed only low activity on survival of newborn rat SCG neurons, this protein was found to increase the expression of vasoactive intestinal peptide and preprotachykinin-A mRNAs in cultured SCG neurons [1].
  • A cocktail of antibodies and binding proteins, directed against endogenous IGF-I, GDNF, and CT-1, significantly decreased mean single-twitch force [14].

Analytical, diagnostic and therapeutic context of GDNF

  • We investigated the location(s), the timing, and the extent to which these GDNF receptors appear in the population of crest-derived precursors that form the avian ENS using immunohistochemistry and in situ hybridization [9].
  • Recent transgenic and organ culture experiments have clearly demonstrated that GDNF is a mesenchyme-derived signaling molecule for the promotion of ureteric branching in kidney development [2].
  • These analyses, using the ELISA assay, did not detect reductions in GDNF in the ethanol-exposed animals [11].


  1. Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. Trupp, M., Rydén, M., Jörnvall, H., Funakoshi, H., Timmusk, T., Arenas, E., Ibáñez, C.F. J. Cell Biol. (1995) [Pubmed]
  2. Other neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF). Saarma, M., Sariola, H. Microsc. Res. Tech. (1999) [Pubmed]
  3. Neurotrophic factors BDNF and GDNF protect embryonic chick spinal cord motoneurons from ethanol neurotoxicity in vivo. Bradley, D.M., Beaman, F.D., Moore, D.B., Kidd, K., Heaton, M.B. Brain Res. Dev. Brain Res. (1999) [Pubmed]
  4. Expression pattern of GDNF, c-ret, and GFRalphas suggests novel roles for GDNF ligands during early organogenesis in the chick embryo. Homma, S., Oppenheim, R.W., Yaginuma, H., Kimura, S. Dev. Biol. (2000) [Pubmed]
  5. Glial cell line-derived neurotrophic factor promotes the development of adrenergic neurons in mouse neural crest cultures. Maxwell, G.D., Reid, K., Elefanty, A., Bartlett, P.F., Murphy, M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  6. GDNF regulates chicken rod photoreceptor development and survival in reaggregated histotypic retinal spheres. Rothermel, A., Layer, P.G. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  7. Differential effects of the trophic factors BDNF, NT-4, GDNF, and IGF-I on the isthmo-optic nucleus in chick embryos. Janiga, T.A., Rind, H.B., von Bartheld, C.S. J. Neurobiol. (2000) [Pubmed]
  8. Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway. Pérez-García, M.J., Ceña, V., de Pablo, Y., Llovera, M., Comella, J.X., Soler, R.M. J. Biol. Chem. (2004) [Pubmed]
  9. Expression of the GDNF receptors ret and GFRalpha1 in the developing avian enteric nervous system. Schiltz, C.A., Benjamin, J., Epstein, M.L. J. Comp. Neurol. (1999) [Pubmed]
  10. Retinoic acid negatively regulates GDNF and neurturin receptor expression and responsiveness in embryonic chicken sympathetic neurons. Doxakis, E., Davies, A.M. Mol. Cell. Neurosci. (2005) [Pubmed]
  11. Prenatal ethanol exposure reduces spinal cord motoneuron number in the fetal rat but does not affect GDNF target tissue protein. Barrow Heaton, M.B., Kidd, K., Bradley, D., Paiva, M., Mitchell, J., Walker, D.W. Dev. Neurosci. (1999) [Pubmed]
  12. Glial cell line-derived neurotrophic factor and target-dependent regulation of large-conductance KCa channels in developing chick lumbar motoneurons. Martin-Caraballo, M., Dryer, S.E. J. Neurosci. (2002) [Pubmed]
  13. Overlapping and specific patterns of GDNF, c-ret and GFR alpha mRNA expression in the developing chicken retina. Karlsson, M., Lindqvist, N., Mayordomo, R., Hallböök, F. Mech. Dev. (2002) [Pubmed]
  14. Role of exogenous and endogenous trophic factors in the regulation of extraocular muscle strength during development. Chen, J., von Bartheld, C.S. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
WikiGenes - Universities