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Gene Review

ANGPT2  -  angiopoietin 2

Gallus gallus

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Disease relevance of ANGPT2

  • Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth [1].

High impact information on ANGPT2

  • POH decreased the release of VEGF from cancer cells but stimulated the expression of Ang2 by endothelial cells, indicating that it might suppress neovascularization and induce vessel regression [2].
  • Genomic structure and alternative splicing of chicken angiopoietin-2 [3].
  • We have sequenced the chicken angiopoietin-2 gene that spans about 46 kb of DNA and is split in 9 exons by 8 introns [3].
  • These observations are in accordance with the proposal that Ang-2 induces angiogenesis in the presence of VEGF and vascular regression in its absence [4].

Biological context of ANGPT2

  • We report here the characterization of a novel form of Ang-2 (Ang-2B) with a truncated amino-terminal domain resulting from an alternative splicing of the gene [4].

Anatomical context of ANGPT2


Other interactions of ANGPT2

  • Testicular regression is accompanied by high expression of Ang-2 and very low expression of VEGF [4].

Analytical, diagnostic and therapeutic context of ANGPT2

  • In this study, we analyzed tumor growth, vascularization, and angiopoietin-2 (Ang2) expression during the development of U-87 MG xenografts [1].


  1. Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth. Lee, O.H., Fueyo, J., Xu, J., Yung, W.K., Lemoine, M.G., Lang, F.F., Bekele, B.N., Zhou, X., Alonso, M.A., Aldape, K.D., Fuller, G.N., Gomez-Manzano, C. Neoplasia (2006) [Pubmed]
  2. Perillyl alcohol is an angiogenesis inhibitor. Loutrari, H., Hatziapostolou, M., Skouridou, V., Papadimitriou, E., Roussos, C., Kolisis, F.N., Papapetropoulos, A. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  3. Genomic structure and alternative splicing of chicken angiopoietin-2. Mezquita, J., Mezquita, P., Montserrat, P., Mezquita, B., Francone, V., Vilagrasa, X., Mezquita, C. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  4. Characterization of a novel form of angiopoietin-2 (Ang-2B) and expression of VEGF and angiopoietin-2 during chicken testicular development and regression. Mezquita, J., Mezquita, B., Pau, M., Mezquita, C. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
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