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Gene Review

CLIP1  -  CAP-GLY domain containing linker protein 1

Gallus gallus

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High impact information on RSN

  • Other highly conserved chicken and human CLIP-170/Restin regions confirm the importance of certain protein domains as crucial for protein function, including two CAP-Gly microtubule-binding motifs in the N-terminal globular head domain and two CCHC metal-binding motifs in the C-terminal globular tail domain [1].
  • Comparison of the levels of CLIP-170 and Restin messages in RNA from chicken and human intestinal epithelial cells revealed remarkably similar ratios in the two species [1].
  • PCR analysis of chicken genomic DNA revealed that all four isoforms result from differential splicing of two exons in a region of the CLIP-170 gene that contains approximately 8.6 kb of intervening sequence [2].
  • Adult chicken cardiac and smooth muscles also express CLIP-170(11) and CLIP-170(11+35), but CLIP-170 is the predominant isoform in these muscles as it is in all other tissues except brain [2].
  • The ratios of CLIP-170 isoform expression found in embryonic and adult chicken cardiac muscles reveal that isoform expression is regulated differentially in different developmental stages as well as in different tissues [2].

Anatomical context of RSN


Analytical, diagnostic and therapeutic context of RSN

  • We have used Southern DNA blot analysis and PCR amplification of exon-intron junctions of chicken genomic DNA to confirm that CLIP-170 and Restin are isoforms encoded by the same gene [1].
  • Semiquantitative RT-PCR analysis of CLIP-170 and Restin mRNA expression revealed expression of both isoforms in a variety of chicken tissues but in different ratios [1].


  1. Cloning and expression of chicken CLIP-170 and restin isoforms. Griparic, L., Volosky, J.M., Keller, T.C. Gene (1998) [Pubmed]
  2. Identification and expression of two novel CLIP-170/Restin isoforms expressed predominantly in muscle. Griparic, L., Keller, T.C. Biochim. Biophys. Acta (1998) [Pubmed]
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